COMPOSITIONS AND METHODS FOR SELECTIVE PROTEIN DEGRADATION

The invention provides compositions including a fusion polypeptide and methods for making a fusion polypeptide that includes a COF1/CRBN-binding polypeptide, COF2/CRBN-binding polypeptide, or COF3/CRBN-binding polypeptide and a heterologous polypeptide of interest.

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Bibliographische Detailangaben
Hauptverfasser:	ROSS, Nathan Thomas, SOLOMON, Jonathan, BECKWITH, Rohan, GOOLD, Carleton, HILD, Marc Horst Peter, GOLOSOV, Andrei, CARBONNEAU, Seth, BRADNER, James, MOTZ, Gregory, GUIMARAES, Carle
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention provides compositions including a fusion polypeptide and methods for making a fusion polypeptide that includes a COF1/CRBN-binding polypeptide, COF2/CRBN-binding polypeptide, or COF3/CRBN-binding polypeptide and a heterologous polypeptide of interest.