PROCESS FOR THE PREPARATION OF N-((1R,2S,5R)-5-(TERT-BUTYLAMINO)-2-((S)-3-(7-TERT-BUTYLPYRAZOLO[1,5-A][1,3,5]TRIAZIN-4-YLAMINO)-2-OXOPYRROLIDIN-1-YL)CYCLOHEXYL)ACETAMIDE

PROCESS FOR THE PREPARATION OF N-((1R,2S,5R)-5-(TERT-BUTYLAMINO)-2-((S)-3-(7-TERT-BUTYLPYRAZOLO[1,5-A][1,3,5]TRIAZIN-4-YLAMINO)-2-OXOPYRROLIDIN-1-YL)CYCLOHEXYL)ACETAMIDE

Title: PROCESS FOR THE PREPARATION OF N-((1R,2S,5R)-5-(TERT-BUTYLAMINO)-2-((S)-3-(7-TERT-BUTYLPYRA- ZOLO[1,5-A][1,3,5]TRIAZIN-4-YLAMINO)-2-0XOPYRROLIDIN-1-YL)CYCLOHEXYL)ACETAMIDE (57) : The invention generally relates to an improved process for the preparation of N-((lR,2S,5R)-5-(tert-butylamino)-24...

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Hauptverfasser: SFOUGGATAKIS, Chris, ZARETSKY, Serge, DOMAGALSKI, Nathan R, EASTGATE, Martin D, RAZLER, Thomas M, LA CRUZ, Thomas E, LAUSER, Kathleen, FENSTER, Michael David Bengt, SOUMEILLANT, Maxime C.D, AYTAR, Burcu Selin, LUO, Helen Y, FAN, Yu, LEE, Hong Geun, LEAHY, David K, KOPP, Nathaniel David, CHAN, Collin, ZHENG, Bin, SAVAGE, Scott A, FOREST, Robert V, GREEN, Rebecca A, HICKEY, Matthew R, DEERBERG, Joerg, GONZALEZ-BOBES, Francisco, BOROVIKA, Alina, ZHU, Ye
Format: Patent
Sprache:eng
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Title: PROCESS FOR THE PREPARATION OF N-((1R,2S,5R)-5-(TERT-BUTYLAMINO)-2-((S)-3-(7-TERT-BUTYLPYRA- ZOLO[1,5-A][1,3,5]TRIAZIN-4-YLAMINO)-2-0XOPYRROLIDIN-1-YL)CYCLOHEXYL)ACETAMIDE (57) : The invention generally relates to an improved process for the preparation of N-((lR,2S,5R)-5-(tert-butylamino)-24(S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2- oxopyrrolidin- 1 -yl)cyclohexyl)acetamide, as well as novel inteiinediates employed in the process, which may be useful for the treatment of cancer. N N N ( N H N O (12) INTERNATIONAL APPLICATION PUBLISHED (19) World Intellectual Property Organization International Bureau UNDER THE PATENT COOPERATION TREATY (PCT) vitivio VIII 00 los OH u oimIE (10) International Publication Number WO 2019/018592 A2 PCT (43) International Publication Date 24 January 2019 (24.01.2019) WIP0 I New Brunswick, New Jersey 08903 (US). GREEN, Rebec- ca A.; c/o Bristol-Myers Squibb Company, 1 Squibb Dri- ve, New Brunswick, New Jersey 08903 (US). HICKEY, Matthew R.; c/o Bristol-Myers Squibb Company, 1 Squibb Drive, New Brunswick, New Jersey 08903 (US). KOPP, Nathaniel David; c/o Bristol-Myers Squibb Company, 1 Squibb Drive, New Brunswick, New Jersey 08903 (US). LA CRUZ, Thomas E.; c/o Bristol-Myers Squibb Com- pany, 1 Squibb Drive, New Brunswick, New Jersey 08903 (US). LAUSER, Kathleen; c/o Bristol-Myers Squibb Com- pany, 1 Squibb Drive, New Brunswick, New Jersey 08903 (US). LEE, Hong Geun; Seoul National University, De- partment of Chemistry 503-620, 1 Gwanak-Ro Gwanak-Gu, Seoul 08826 (KR). LEAHY, David K.; 10 Ida Road, Mar- blehead, MA 01945 (US). LUO, Helen Y.; c/o Bristol-My- ers Squibb Company, 1 Squibb Drive, New Brunswick, New Jersey 08903 (US). RAZLER, Thomas M.; c/o Bristol-Myers Squibb Company, 1 Squibb Drive, New Brunswick, New Jersey 08903 (US). SAVAGE, Scott A.; c/o Bristol-Myers Squibb Company, 1 Squibb Drive, New Brunswick, New Jersey 08903 (US). SFOUGGATAKIS, Chris; c/o Bristol-Myers Squibb Company, 1 Squibb Dri- ve, New Brunswick, New Jersey 08903 (US). SOUMEIL- LANT, Maxime C.D.; c/o Bristol-Myers Squibb Compa- ny, 1 Squibb Drive, New Brunswick, New Jersey 08903 (US). ZARETSKY, Serge; c/o Bristol-Myers Squibb Com- pany, 1 Squibb Drive, New Brunswick, New Jersey 08903 (US). ZHENG, Bin; c/o Bristol-Myers Squibb Company, 1 Squibb Drive, New Brunswick, New Jersey 08903 (US). ZHU, Ye; 111 Clementi Road, #07-02, Singapore 129792 (SG). (74) Agent: KORSEN, Elliott et al.; Bristol-Myers Squibb Company, Route 206 & Prov