SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS NADPH OXIDASE INHIBITORS

International Patent Classification: C07D 471/04 (2006.01) A61P 35/00 (2006.01) C07D 491/052 (2006.01) A61K 31/437 (2006.01) CO7D 495/04 (2006.01) A61K 31/5377 (2006.01) CO7D 498/04 (2006.01) A61K 31/444 (2006.01) CO7D 513/04 (2006.01) A61K 31/496 (2006.01) A61P 11/00 (2006.01) A61K 31/4545 (2006.01) (21) International Application Number: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 November 2018 (08.11.2018) WIPO I PCT 01E101°1a °nolo oloionoolomim io Elio ow (10) International Publication Number WO 2018/203298 Al PCT/IB2018/053121 (22) International Filing Date: 04 May 2018 (04.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 201721015787 04 May 2017 (04.05.2017) IN (71) Applicant: GLENMARK PHARMACEUTICALS S.A. [CH/CH]; Chemin de la Combeta 5, 2300 La Chaux-de- Fonds (CH). (72) Inventors: KUMAR, Sukeerthi; 404A, Vardhaman En- clave, Plot No. 3, Sector-20, Airoli, Maharasthra, Navi Mumbai 400708 (IN). CHAUDHARI, Sachin Sundar- lal; 15/304, FAM C.H.S., Sector # 11, Koparkhairane, Maharashtra, Navi Mumbai 400709 (IN). GHARAT, Laxmikant Atmaram; Flat No-203, Tirupati Apartments, Pokhran road no - 2, Majiwada, Maharashtra, Thane (W) 400601 (IN). KHAIRATKAR-JOSHI, Neelima; C-101, Devprayag CHS, Bhakti Mandir Rd, Hari Niwas, Panch- pakhadi, Maharashtra, Thane (W) 400602 (IN). SHAH, Daisy Manish; Padmashree Bldg, 1st Floor, Flat no 4, Anant Patil Marg, Gokhale Road, Dadar (W), Mumbai 400028 (IN). MUKHOPADHYAY, Indranil; Flat No. 502, 'LILY' Kesar Garden, Plot- 53, Sector-20, Kharghar, Maharashtra, Navi Mumbai 410210 (IN). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), E