USE OF KLK5 ANTAGONISTS FOR TREATMENT OF A DISEASE

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 25 October 2018 (25.10.2018) WIP0 I PCT onion °nolo mu ioo Ho oimIE (10) International Publication Number WO 2018/195472 Al (51) International Patent Classification: A61K 38/00 (2006.01) C07K 14/81 (2006.01) (21) International Application Number: PCT/US2018/028637 (22) International Filing Date: 20 April 2018 (20.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/488,515 21 April 2017 (21.04.2017) US (71) Applicant (for all designated States except AL, AT, BA, BE, BG, CH, CN, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IN, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR): GENENTECH, INC. [US/US]; 1 DNA Way, South San Francisco, Califor- nia 94080 (US). (71) Applicant (for AL, AT, BA, BE, BG, CH, CN, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IN, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR only): F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124, 4070 BASEL (CH). (72) Inventors: DRESSEN, Amy; c/o Genentech, Inc., 1 DNA Way, South San Francisco, California 94080 (US). IAEA, David B.; c/o Genentech, Inc., 1 DNA Way, South San Francisco, California 94080 (US). ISMAILI, Moulay Hicham Alaoui; 128 Seville Way, San Mateo, California 94402 (US). JACKMAN, Janet K.; c/o Genentech, Inc., 1 DNA Way, South San Francisco, California 94080 (US). LAZARUS, Robert A.; c/o Genentech, Inc., 1 DNA Way, South San Francisco, California 94080 (US). LOYET, Kel- ly; c/o Genentech, Inc., 1 DNA Way, South San Francis- co, California 94080 (US). MAUN, Henry R.; Grenzach- erstrasse 124, 4070 Basel (CH). YASPAN, Brian L.; c/o Genentech, Inc., 1 DNA Way, South San Francisco, Cali- fornia 94080 (US). YI, Tangsheng; c/o Genentech, Inc., 1 DNA Way, South San Francisco, California 94080 (US). ARRON, Joseph R.; c/o Genentech, Inc., 1 DNA Way, South San Francisco, California 94080 (US). HERNAN- DEZ-BARRY, Hilda Y.; c/o Genentech, Inc., 1 DNA Way, South San Francisco, California 94080 (US). CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, S