METHODS FOR CRYOGENIC STORAGE

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 20 September 2018 (20.09.2018) WIP0 I PCT o n °nolo olo VIII (10) International Publication Number WO 2018/170188 A2 (51) International Patent Classification: AO1N 1/02 (2006.01) A61K 35/17 (2015.01) (21) International Application Number: PCT/US2018/022522 (22) International Filing Date: Published: without international search report and to be republished upon receipt of that report (Rule 48.2(g)) 14 March 2018 (14.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/471,343 14 March 2017 (14.03.2017) US (71) Applicant: JUNO THERAPEUTICS, INC. [US/US]; 400 Dexter Avenue North, Suite 1200, Seattle, Washington 98109 (US). (72) Inventors; and (71) Applicants: CHURCH, Sara Elizabeth [US/US]; 400 Dexter Avenue North, Suite 1200, Seattle, Washington 98109 (US). GUNTHER, Jon Charles [US/US]; 400 Dex- ter Avenue North, Suite 1200, Seattle, Washington 98109 (US). POLLOCK, Kathryn [US/US]; 400 Dexter Avenue North, Suite 1200, Seattle, Washington 98109 (US). (74) Agent: MURPHY, Amanda K.; Finnegan, Henderson, Farabow, Garrett & Dunner LLP, 901 New York Avenue NW, Washington, District of Columbia 20001-4413 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: METHODS FOR CRYOGENIC STORAGE (57) : The present disclosure relates to methods and compositions a