ANTICANCER COMPOUNDS

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 20 September 2018 (20.09.2018) WIPO I PCT onion °nolo momioomi olomoilowo oimIE (10) International Publication Number WO 2018/167270 Al (51) International Patent Classification: C07D 407/12 (2006.01) A61P 35/00 (2006.01) A61K 31/351 (2006.01) (21) International Application Number: PCT/EP2018/056665 (22) International Filing Date: 16 March 2018 (16.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 17382140.6 17 March 2017 (17.03.2017) EP (71) Applicant: PHARMA MAR, S.A. [ES/ES]; Avenida de los Reyes, 1, E-28770 Colmenar Viejo-Madrid (ES). (72) Inventors: CASEDO HERNANDEZ, Librada Maria; PHARMA MAR, S.A., Avenida de los Reyes, 1, Poligono Industrial La Mina-Norte, E-28770 Colmenar Viejo-Madrid (ES). DE LA CALLE VERDU, Fernando; PHARMA MAR, S.A., Avenida de los Reyes, 1, Poligono Industri- al La Mina-Norte, E-28770 Colmenar Viejo-Madrid (ES). RODRIGUEZ RAMOS, Maria Pilar; PHARMA MAR, S.A., Avenida de los Reyes, 1, Poligono Industrial La Mi- na-Norte, E-28770 Colmenar Viejo-Madrid (ES). SCH- LEISSNER SANCHEZ, Maria del Carmen; PHARMA MAR, S.A., Avenida de los Reyes, 1, Poligono Industrial La Mina-Norte, E-28770 Colmenar Viejo-Madrid (ES). ZUNI- GA GIRON, Paz; PHARMA MAR, S.A., Avenida de los Reyes, 1 Poligono Industrial La Mina-Norte, E-28770 Col- menar Viejo-Madrid (ES). (74) Agent: BERNARDO NORIEGA, Francisco; ABG PATENTES, S.L., Avda. de Burgos, 16D , Edificio EURO- MOR, E-28036 Madrid (ES). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE,