ANTAGONIST ANTIBODIES THAT T BIND TO HUMAN TGFB1, TGFB2 AND TO TGFB3 AND THEIR USE FOR THE TREATMENT OF LUNG FIBROSIS

ANTAGONIST ANTIBODIES THAT T BIND TO HUMAN TGFB1, TGFB2 AND TO TGFB3 AND THEIR USE FOR THE TREATMENT OF LUNG FIBROSIS

The present disclosure relates to TGF-beta antibodies and binding fragments thereof, DNA encoding the same, host cells comprising said DNA and methods of expressing the antibody or binding fragment in a host cell. The disclosure also extends to pharmaceutical compositions comprising the antibody or...

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Bibliographische Detailangaben
Hauptverfasser: ELLIS, Mark, JUPP, Raymond Anthony, GOUVEIA SANCHO, Maria Margarida, COMPSON, Joanne Elizabeth, KEVORKIAN, Lara, PAYNE, Andrew Charles, LIGHTWOOD, Daniel John, DOYLE, Carl Brendan, RASTRICK, Joseph Michael David, DIXON, Kate Louise, SCHULZE, Monika-Sarah, TYSON, Kerry Louise, MARSHALL, Diane, TURNER, Alison, BON, Helene
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present disclosure relates to TGF-beta antibodies and binding fragments thereof, DNA encoding the same, host cells comprising said DNA and methods of expressing the antibody or binding fragment in a host cell. The disclosure also extends to pharmaceutical compositions comprising the antibody or a binding fragment thereof and use of the antibody, binding fragment and compositions comprising the same in treatment of various diseases including fibrosis.