HEPATITIS B TREATMENT VACCINE BASED ON INACTIVATED WHOLE RECOMBINANT HANSENULA CELL WHICH EXPRESSES HBSAG AND HBCAG

Provided is a hepatitis B treatment vaccine based on an inactivated whole recombinant Hansenula cell which expresses HBsAg and HBcAg. An HBsAgVLP and an HBcAgVLP expressed in the recombinant Hansenula cell are used as antigens, the amino acid sequence of the HBsAg expressed by the recombinant Hansen...

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Bibliographische Detailangaben
Hauptverfasser:	WANG, Changhua, YANG, Jun, WANG, Hemu
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided is a hepatitis B treatment vaccine based on an inactivated whole recombinant Hansenula cell which expresses HBsAg and HBcAg. An HBsAgVLP and an HBcAgVLP expressed in the recombinant Hansenula cell are used as antigens, the amino acid sequence of the HBsAg expressed by the recombinant Hansenula contains a total of 19 CTL epitopes, the amino acid sequence of the HBcAg expressed by the recombinant Hansenula contains a total of 19 CTL epitopes, and the inactivated whole recombinant Hansenula cell is used as an adjuvant.