FUSED PENTACYCLIC IMIDAZOLE DERIVATIVES

A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nocice...

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Hauptverfasser:	FORICHER, YANN, DELIGNY, MICHAEL, MAC COSS, MALCOLM, DE HARO GARCIA, TERESA, HEER, JAG PAUL, XUAN, MENGYANG, CALMIANO, MARK DANIEL, SELBY, MATTHEW DUNCAN, JOHNSON, JAMES ANDREW, QUINCEY, JOANNA RACHEL, SWINNEN, DOMINIQUE LOUIS LÉON, SHAW, MICHAEL ALAN, ZHU, ZHAONING, FILOCHE-ROMME, BRUNO, SCHIO, LAURENT, BROOKINGS, DANIEL CHRISTOPHER, JADOT, SOPHIE, EVRARD, YVES, HUTCHINGS, MARTIN CLIVE, KEYAERTS, JEAN
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. In particular, the present invention is concerned with 6, 7-dihydro-7, 14-methanobenzimidazo[1, 2-b][2,5]benzodiazocin-5(14H)-one derivatives and analogs thereof.