POLYPEPTIDE CONSTRUCTS AND USES THEREOF

POLYPEPTIDE CONSTRUCTS AND USES THEREOF

The present invention provides a polypeptide construct comprising a peptide or polypeptide signaling ligand linked to an antibody or antigen binding portion thereof which binds to a cell surface-associated antigen, wherein the ligand comprises at least one amino acid substitution or deletion which r...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MIKESELL, GLEN E, TAURA, TETSUYA, TRAN, STEPHEN, WILSON, JR, DAVID S, KORVER, WOUTER, POGUE, SARAH L, DOYLE, ANTHONY, G, CLARKE, ADAM, POLLARD, MATTHEW, LIN, JACK TZUIAO
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:The present invention provides a polypeptide construct comprising a peptide or polypeptide signaling ligand linked to an antibody or antigen binding portion thereof which binds to a cell surface-associated antigen, wherein the ligand comprises at least one amino acid substitution or deletion which reduces its potency on cells lacking expression of said antigen.