MODULATOR OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, PHARMACEUTICAL COMPOSITIONS, METHODS OF TREATMENT, AND PROCESS FOR MAKING THE MODULATOR

MODULATOR OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, PHARMACEUTICAL COMPOSITIONS, METHODS OF TREATMENT, AND PROCESS FOR MAKING THE MODULATOR

Compounds of Formula (I):pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the s...

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Hauptverfasser: KHATUYA, Haripada, MCCARTNEY, Jason, TERMIN, Andreas, ABELA, Alexander, CLEVELAND, Thomas, KANG, Ping, MILLER, Mark, KESHAVARZ-SHOKRI, Ali, YOUNG, Tomothy, STAVROPOULOS, Kathy, ALCACIO, Timothy, HADIDA RUAH, Sara, KRENITSKY, Paul, BAEK, Minson, SHI, Yi, SHRESTHA, Muna, ZHOU, Jinglan, ANDERSON, Corey, VAN GOOR, Fredrick, GROOTENHUIS, Peter Diederik, PARASELLI, Prasuna, SIESEL, David, GROSS, Raymond, FERRIS, Lori, GULEVICH, Anton, HSIA, Clara, HUGHES, Robert, JOSHI, Pramod, UY, Johnny, PIERRE, Fabrice Jean, CLEMENS, Jeremy, ANGELL, Paul
Format: Patent
Sprache:eng
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Zusammenfassung:Compounds of Formula (I):pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.