METHOD OF MANUFACTURING BISPECIFIC ANTIBODIES, BISPECIFIC ANTIBODIES AND THERAPEUTIC USE OF SUCH ANTIBODIES

METHOD OF MANUFACTURING BISPECIFIC ANTIBODIES, BISPECIFIC ANTIBODIES AND THERAPEUTIC USE OF SUCH ANTIBODIES

The invention relates to bivalent bispecific monoclonal antibodies (bbmAb) or variants thereof, and methods of manufacturing such antibodies by co-expressing modified Fc-mutated derivatives of two different monoclonal antibodies in mammalian cell lines.

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Bibliographische Detailangaben
Hauptverfasser: JOSTOCK, Thomas, BUCH, Tina, WOISETSCHLAEGER, Maximilian, GRAF, Christian, KNOPF, Hans-Peter, KOEHLER, Rolf, KOVARIK, Jiri, HEITMANN, Daniel, BARDROFF, Michael Otto, OLIVER, Stephen John, PATEL, Dhavalkumar
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention relates to bivalent bispecific monoclonal antibodies (bbmAb) or variants thereof, and methods of manufacturing such antibodies by co-expressing modified Fc-mutated derivatives of two different monoclonal antibodies in mammalian cell lines.