CALICHEAMICIN DERIVATIVE-CARRIER CONJUGATES
Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with dicreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the...
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| creator | MARK EDWARD RUPPEN JUSTIN KEITH MORAN EUGENE JOSEPH VIDUNAS JOHN MCLEAN SIMPSON PAUL DAVID ROBBINS NEERA JAIN NITIN KRISHNAJI DAMLE JOHN FRANCIS DIJOSEPH ANDREW GEORGE POPPLEWELL ARTHUR KUNZ NISHITH MERCHANT JOSEPH THOMAS RUBINO |
| description | Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with dicreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. |
| format | Patent |
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Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.</description><language>eng</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170227&DB=EPODOC&CC=SG&NR=10201700289RA$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25555,76308</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170227&DB=EPODOC&CC=SG&NR=10201700289RA$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MARK EDWARD RUPPEN</creatorcontrib><creatorcontrib>JUSTIN KEITH MORAN</creatorcontrib><creatorcontrib>EUGENE JOSEPH VIDUNAS</creatorcontrib><creatorcontrib>JOHN MCLEAN SIMPSON</creatorcontrib><creatorcontrib>PAUL DAVID ROBBINS</creatorcontrib><creatorcontrib>NEERA JAIN</creatorcontrib><creatorcontrib>NITIN KRISHNAJI DAMLE</creatorcontrib><creatorcontrib>JOHN FRANCIS DIJOSEPH</creatorcontrib><creatorcontrib>ANDREW GEORGE POPPLEWELL</creatorcontrib><creatorcontrib>ARTHUR KUNZ</creatorcontrib><creatorcontrib>NISHITH MERCHANT</creatorcontrib><creatorcontrib>JOSEPH THOMAS RUBINO</creatorcontrib><title>CALICHEAMICIN DERIVATIVE-CARRIER CONJUGATES</title><description>Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with dicreased aggregation and low conjugate fraction (LCF) are described. 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Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | CALICHEAMICIN DERIVATIVE-CARRIER CONJUGATES |
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