CALICHEAMICIN DERIVATIVE-CARRIER CONJUGATES

CALICHEAMICIN DERIVATIVE-CARRIER CONJUGATES

Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with dicreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the...

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Bibliographische Detailangaben
Hauptverfasser: MARK EDWARD RUPPEN, JUSTIN KEITH MORAN, EUGENE JOSEPH VIDUNAS, JOHN MCLEAN SIMPSON, PAUL DAVID ROBBINS, NEERA JAIN, NITIN KRISHNAJI DAMLE, JOHN FRANCIS DIJOSEPH, ANDREW GEORGE POPPLEWELL, ARTHUR KUNZ, NISHITH MERCHANT, JOSEPH THOMAS RUBINO
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with dicreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.