SETT ATT FRAMSTELLA 3,4-DISUBSTITUERADE 2-(BETA-NAFTYL-OXI)-ETYLPYRAZOLONER OCH ANVENDNING DERAV SOM LEKEMEDEL

SETT ATT FRAMSTELLA 3,4-DISUBSTITUERADE 2-(BETA-NAFTYL-OXI)-ETYLPYRAZOLONER OCH ANVENDNING DERAV SOM LEKEMEDEL

Pyrazolones of formula (I) are novel cpds. including the tautomeric forms. (where R1 = H, CF3 or alkyl, aryl, aralkyl or heteroaryl each of which may be substd; R2 = opt. substd. alkyl, aryl, aralkyl, trihalomethyl-mercapto, alkoxy or aryloxy; R3 = naphthyl which may be substd. by 1-3 groups chosen...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: H HORSTMANN, F SEUTER, K-A MENG, E MOLLER
Format: Patent
Sprache:swe
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Pyrazolones of formula (I) are novel cpds. including the tautomeric forms. (where R1 = H, CF3 or alkyl, aryl, aralkyl or heteroaryl each of which may be substd; R2 = opt. substd. alkyl, aryl, aralkyl, trihalomethyl-mercapto, alkoxy or aryloxy; R3 = naphthyl which may be substd. by 1-3 groups chosen from halo, CF3, alkyl alkenyl, alkoxy, alkylamino, cyano, CF3O-, nitro, hydroxy, -SOn-alkyl or -SOn-CF3 and n = 0-2). (I) are antithrombotic cpds. which may be administered orally or parenterally for therapeutic or prophylactic treatment of thrombo-embolic disorders, blood clots etc. Pref. daily doses are 0.1-10 mg/kf parenterally or 0.5-100 mg/kg orally, formulated by usual methods.