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5 alpha , 17B-Diacetoxy-6 -chloro-2 alpha , 3 alpha ; 16 alpha , 17 alpha -diepoxy-androstane; 5 alpha , 17B-Dicetoxy-6 -chloro-androsta-2,16-diene; 5 alpha -Hydroxy-6 -chloro-17-oxo-androst-2-ene or a like intermediate in the production of curare-like compounds is produced by reacting 5 alpha , 6B-...

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Bibliographische Detailangaben
Hauptverfasser:	APPEL M, RUTKOWSKI E V, OGREN J R
Format:	Patent
Sprache:	swe
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS STEROIDS
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Beschreibung
Zusammenfassung:	5 alpha , 17B-Diacetoxy-6 -chloro-2 alpha , 3 alpha ; 16 alpha , 17 alpha -diepoxy-androstane; 5 alpha , 17B-Dicetoxy-6 -chloro-androsta-2,16-diene; 5 alpha -Hydroxy-6 -chloro-17-oxo-androst-2-ene or a like intermediate in the production of curare-like compounds is produced by reacting 5 alpha , 6B-dihydroxy-17-oxo-androst-2-ene with an organic sulfonic acid chloride. The obtained 5 alpha - hydroxy-6B-chloro-17-oxo-androst-2-ene can then be reacted with the enol acetate of a ketone having 3 to 5 carbon atoms to yield 5 alpha , 17B-diacetoxy-6B-chloro-androsta-2,16-diene. The latter is treated to yield the corresponding diepoxide.