SETT ATT FRAMSTELLA N-METYL-N-(3,4,5-TRIMETOXIBENSYL)-2,3-DIMETYL-2,4-PENTADIENAMIN

SETT ATT FRAMSTELLA N-METYL-N-(3,4,5-TRIMETOXIBENSYL)-2,3-DIMETYL-2,4-PENTADIENAMIN

1,3,4-Trimethyl-1-(3,4,5-trimethoxybenzyl)-1,2,5,6-tetrahydro-pyrid ine chloride and N-methyl-N-(3,4,5-trimethoxybenzyl)-2,3-dimethyl-2,4-pentadienamine (formula I), which can be used as painkillers, are obtained by initially refluxing, in a first synthesis step, 3,4,5-trimethoxybenzyl chloride with...

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Bibliographische Detailangaben
Hauptverfasser: MARTINEZ ROLDAN C, RABADAN PEINADO F, BOSCH CARTES J, GRANADOS JARQUE R, CANALS CABIRO J
Format: Patent
Sprache:swe
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:1,3,4-Trimethyl-1-(3,4,5-trimethoxybenzyl)-1,2,5,6-tetrahydro-pyrid ine chloride and N-methyl-N-(3,4,5-trimethoxybenzyl)-2,3-dimethyl-2,4-pentadienamine (formula I), which can be used as painkillers, are obtained by initially refluxing, in a first synthesis step, 3,4,5-trimethoxybenzyl chloride with 1,3,4-trimethyl-1,2,5,6-tetra-hydropyridine in an anhydrous solvent, from which reaction mixture 1,3,4-trimethyl-1-(3,4,5-trimethoxybenzyl)-1,2,5,6-tetrahydropyridine chloride is formed upon cooling. This compound is subsequently subjected, in a second step, to a degradation reaction by boiling it over a prolonged period in an aqueous solution of an alkaline metal hydroxide, giving the compound of the formula (I).