SETT ATT FRAMSTELLA KONDENSERADE PYRIMIDINFORENINGAR, MED BROHUVUDSKVEVEATOM, SALTER, HYDRAT OCH ISOMERER DERAV

A process is disclosed for the preparation of compounds of the formula (I) wherein R1 and R2 are each hydrogen or lower alkyl; R3 is carboxy, lower alkoxycarbonyl, carbamoyl, carbamoyl substituted by one or two lower alkyl groups, or cyano; R4 is hydrogen, lower alkyl, phenyl, naphthyl, phenyl or na...

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Hauptverfasser: 2)T BREINING, 4)A HORVATH, 1)I HERMECZ, 5)J KOKOSI, 3)L VASVARI
Format: Patent
Sprache:swe
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Zusammenfassung:A process is disclosed for the preparation of compounds of the formula (I) wherein R1 and R2 are each hydrogen or lower alkyl; R3 is carboxy, lower alkoxycarbonyl, carbamoyl, carbamoyl substituted by one or two lower alkyl groups, or cyano; R4 is hydrogen, lower alkyl, phenyl, naphthyl, phenyl or naphthyl substituted by at least one fluoro, chloro, bromo, iodo, lower alkyl, lower alkoxy, hydroxy, carboxy, or phenyl, pyridyl or tetrazolyl; and R5 is hydrogen or lower alkyl; or a pharmaceutically acceptable salt, hydrate, stereoisomer, optically active isomer, geometric isomer, or tautomer thereof, which comprises the step of aminating a racemic or optically active compound of the formula (II) wherein X is halogen with a compound of the formula (III) or a pharmaceutically acceptable acid addition salt thereof. The compound of formula (II) possess antiallergic, especially antiasthma, activity.