2-(o-carboxyphenylamino)-6H-pyrimido(2,1-b)quinazoline and derivative thereof and compositions thereof

Pharmaceutically usable 2-(o-carboxyphenylamino)-6H-pyrimido(2,1-b)quinazoline 6 with the formulaFurther derivative of this compound with the formulawhere A+ is an alkaline metal, monoethanolamine or diethylamine.IN addition a derivative of the stated compound with the formulawhere R represents OH o...

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Hauptverfasser: 15)J D USENKO, 11)J N DOBROVOLSKY, 14)G A GETMAN, 17)N F DANILEVSKY, 1)V A PORTNYAGINA, 2)V K KARP, 9)A G PANTELEIMONOV, 5)N A MOKHORT, 13)A A MEDVEDOVSKY, 8)T K RYABUKHA, 12)L M KIRICHEK, 6)A G FADEICHEVA, 18)Y P SOLSKY, 7)G I KOZHUSHKO, 4)F P TRINUS, 10)V V KLJUSHIN, 16)V M SIDELNIKOV, 3)I S BARKOVA
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Sprache:eng ; swe
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Zusammenfassung:Pharmaceutically usable 2-(o-carboxyphenylamino)-6H-pyrimido(2,1-b)quinazoline 6 with the formulaFurther derivative of this compound with the formulawhere A+ is an alkaline metal, monoethanolamine or diethylamine.IN addition a derivative of the stated compound with the formulawhere R represents OH or alkyloxide with 1-4 carbon atoms or NHR2, where R1 represents H, alkyl with 1-4 carbon atoms or phenyl as well as alkyl and A are salts of inorganic acids.The final derivative of the given compound with the formulawhere R represents alkyloxide with 1-4 carbon atoms or R1 represents alkyl with 1-4 carbon atoms.Furthermore, a process for producing the given formula comprising in that 2.4 dichloropyrimidine is converted with a sodium salt of anthranilic acid or subtitesters or amides of anthranilic acid in a hydrous or an organic solution at 90-120 degrees C for several hours.Furthermore, this refers to a hemotherapeutic composition, in which the component contains the above given compound or that and a pharmaceutically approved carrier material.