FORFARANDE FOR UTVINNING AV ANTIBIOTIKUMET TIENAMYCIN

A method of recovering the antibiotic thienamycin from fermentation broths or solutions containing said antibiotic, which consists in passing a fermentation broth or a solution containing said antibiotic through a column filled with a cation exchange resin containing sulfonic acid exchanger groups;...

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Bibliographische Detailangaben
Hauptverfasser:	R T GOEGELMAN, F M KAHAN
Format:	Patent
Sprache:	swe
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	A method of recovering the antibiotic thienamycin from fermentation broths or solutions containing said antibiotic, which consists in passing a fermentation broth or a solution containing said antibiotic through a column filled with a cation exchange resin containing sulfonic acid exchanger groups; eluting the adsorbate in resin with a base; collect the eluates; combining the active fractions and passing said combined fractions through a column filled with polyacrylamide or dextran gel that excludes molecules with a molecular weight higher than 1800 and 700 respectively; elute the gel with water or with an aqueous solution of a lower alcohol; collect the eluates and combine the active fractions. (Machine-translation by Google Translate, not legally binding)