POLYAMINFORENINGAR TILL ANVENDNING SOM ETT ANTIMIKROBIELLT MEDEL FOR VEXTER OCH SOM ALGINHIBITORER

1. A method of preparing new polyamines of the formula: **(See formula)** where A is cyclohexyl **(See formula)** where each symbol R is hydrogen or C1-C6 alkyl the symbols n are the same or different and represent the integer 0 or 1; symbols R1 are the same or different and represent C1-C4 alkylene...

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Hauptverfasser: B E WITZEL, R A DYBAS, N GRIER, R A STRELITZ
Format: Patent
Sprache:swe
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Zusammenfassung:1. A method of preparing new polyamines of the formula: **(See formula)** where A is cyclohexyl **(See formula)** where each symbol R is hydrogen or C1-C6 alkyl the symbols n are the same or different and represent the integer 0 or 1; symbols R1 are the same or different and represent C1-C4 alkylene; Z is (see formula) where R5 is hydrogen, aminoethyl, aminopropyl, C1-C4 hydroxyalkyl or C2-C4 dihydroxyalkyl and R6 is hydrogen, C1-C4 hydroxyalkyl or C2-C4 dihydroxyalkyl; when Y is (see formula) R2 is 2-hydroxy-1,3-trimethylene or defined above; R3 is hydrogen, C1-C4 alkyl, C2-C4 aminoalkyl, -C1-C4-hydroxyalkyl or C2-C4 dihydroxyalkyl; R4 is 2-hydroxy-1,3-trimethylene or R1 defined above; or when R3 and R6 bound are ethylene, R4 is also ethylene and R5 is aminoethyl, aminopropyl or aminohydroxypropyl; when Y is **(See formula)** R7 is R2, methylene or a chemical bond between the cyclohexylene radical and a first nitrogen; R8 is R4, methylene or a chemical bond between the cyclohexylene radical and a second nitrogen; when Y is -R2-, R2 R5 and R6 are as defined above; and its acceptable acid addition salts, whose procedure consists of a) reduce a Schiff base of formula: **(See formula)** where A is cyclohexyl or cyclohexenyl of the formula: **(See formula)** where the dotted line represents a double bond and n and Z are those defined above, with hydrogen in the presence of a hydrogenation catalyst and, of an inert solvent, at room temperature or heating and pressure, and b) optionally, reacting the product obtained in the previous step with a compound of formula HX, which is an organic or inorganic, monobasic or polybasic acid, in an amount sufficient to protonate at least one amino group of said compound. (Machine-translation by Google Translate, not legally binding)