ANALOGIFORFARANDE FOR FRAMSTELLNINH AV 1-(2'-AROYL-1'-ETYL)-2-(4"-ACETAMIDO-1"-PIPERAZINYLMETYL)-BENSIMIDAZOLER

Preparation process of new (aroyl-2'-et-1'-yl)-l-(acetamido-4"-piperazin-l"-yl-methyl) -2-benzimidazoles, corresponding to the following formula (I) ; ** (see formula) ** Wherein: Ar denotes a phenyl nucleus optionally substituted by an alkoxy group consisting of a maximum of 4 carbon atoms, by an alkyl group consisting of 1 to 4 carbon atoms, by a nitro group or by a halogen atom, or a α-furyl or α-thienyl radical, and R denotes: a group -NH2, a group -NHR', wherein R' represents an alkyl group consisting of 1 to 4 carbon atoms, or a cycloalkoxy group which consists of a maximum of 6 carbon atoms, or a group -NR1R2 in which R1 and R2 designate an alkyl group consisting of 1 to 4 carbon atoms or form together with the nitrogen atom to which they are attached, a heterocyclic radical chosen from the following: piperidino, pyrrolidino, morpholino and hexamethyleneimino, characterized in that it consists in condensing a compound of the formula (II): ** (see formula) ** Wherein ar has the same meaning as in the formula (I), with a piperazine of the formula (III) ** (see formula) ** In which R has the same meaning as in formula (I). (Machine-translation by Google Translate, not legally binding)