FORFARANDE FOR FRAMSTELLNING AV 7BETA-AMINO-7ALFA-METOXICEFALOSPORINESTRAR

FORFARANDE FOR FRAMSTELLNING AV 7BETA-AMINO-7ALFA-METOXICEFALOSPORINESTRAR

Process for preparing 7- beta -Amino-7- alpha -methoxycephalosporin esters WHEREIN Z is H or an organic radical, eg. acetoxy, methoxy, carbamoyloxy or 5-thio-1-methyltetrazol; comprising low temperature 7-methoxylation of a 7-(p-nitrobenzyloxycarbamido) cephalosporin ester; reduction of the methoxyl...

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Bibliographische Detailangaben
Hauptverfasser: W H W LUNN, G A KOPPEL
Format: Patent
Sprache:swe
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Process for preparing 7- beta -Amino-7- alpha -methoxycephalosporin esters WHEREIN Z is H or an organic radical, eg. acetoxy, methoxy, carbamoyloxy or 5-thio-1-methyltetrazol; comprising low temperature 7-methoxylation of a 7-(p-nitrobenzyloxycarbamido) cephalosporin ester; reduction of the methoxylation product to an intermediate reduction product; and treatment of the reduction product with silica gel. Methoxy amine nucleus esters are valuable intermediates for synthesis of antibiotics.