JODERADE BENSENDERIVAT TILL ANVENDNING SOM KONTRASTMEDIER FOR RADIOGRAFI

1436357 Substituted - N - gluconyl anilines LABORATOIRES ANDRE GUERBET 27 Nov 1974 [7 Dec 1973] 56831/73 Heading C2C [Also in Division A5] Novel compounds of Formula I wherein R1 is H or C 1 -C 4 alkyl, R2 is where each of R4 and R6 is H C 1 -C 4 alkyl or C 1 -C 4 hydroxyalkyl, R3 is CONR6R7 where each of R6 and R7 is as for R4 and R5 or in a radical of formula (II) wherein R7 is H or C 1 -C 4 alkyl and R8 is a C 1 -C 4 alkyl are prepared by action of an acid halide of formula HalCO-(CHOH) 5 H or a penta-acylated derivative is reacted with a compound of Formula III 2,4,6 - Tri - iodo - 3 - (N - methyl - carbamyl)- 5 - (N - hydroxyethylcarbamyl)- analine is prepared by reaction of iodine chloride on the dehalo compound obtained from methylamine and 3 - amino - 5 - (N - hydroxy - ethylcarbamyl)- benzoic acid methyl ester prepared from the acid and methanol.