FORFARANDE FOR FRAMSTELLNING AV NYA 2-AMINOALKYLAMINO-TIENO(3,2-D)-PYRIMIDINER

A process for the preparation of new 2-amino-alcoholylamino-thieno [3,2-d] pyrimidines of the general formula I **(See formula)** in which R1 and R2, which may be the same or different from each other, represent hydrogen atoms or straight or branched chain alcohol radicals with 1 to 6 carbon atoms, the radicals R1 and R2 being able to form, together with the nitrogen atom Also located between them is a saturated, 5- to 7-membered monocyclic, heterocyclic ring, which may optionally be interrupted by an oxygen atom and another nitrogen atom and/or may be substituted by an alcohol radical or a hydroxyl group; R3 means a hydrogen atom or a branched or straight chain alcohol radical with 1 to 6 carbon atoms; R4 signifies a hydrogen atom or a methyl group in position 6 or 7; and A signifies a straight or branched chain alcoholic group with 2 to 10 carbon atoms, as well as its acid addition salts physiologically compatible with organic or inorganic acids, characterized in that a compound of the general formula II is reacted **(See formula)** wherein A, R1, R2, R3 and R4 are as initially defined and Z'' means a halogen atom, with ammonia or with a carboxylic acid amide or imide or with its metal salts; and in the case of a reaction with a carboxylic acid amide or imide or with a metal salt of the carboxylic acid imide, the carboxylic acid derivative is then separated from the resulting carboxylic acid derivative with acids or with bases, and if desired, a compound of formula I obtained is then transformed into its salts by the addition of acid with organic or inorganic acids. (Machine-translation by Google Translate, not legally binding)