SE368403

SE368403

1278164 Ozonides; benzodiazepines SUMITOMO CHEMICAL CO Ltd 13 April 1970 [16 April 1969 29 May 1969] 17436/70 Heading C2C Ozonides and benzodiazepines are prepared by the following route (R 1 =H, halogen, C 1-4 alkyl, NO 2 CF 3 ; R 2 =H, halogen; R 3 , 4 =H, C 1-4 alkyl; X=halogen), optionally follo...

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Hauptverfasser: HORIHASHI T,JA, OKAMOTO T,JA, YAMAMOTO M,JA, ISHIZUMI K,JA, INABA S,JA, KOABAYASHI T,JA, IZUMI T,JA, YAMAMOTO H,JA, MORI K,JA, MARUYAMA I,JA
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:1278164 Ozonides; benzodiazepines SUMITOMO CHEMICAL CO Ltd 13 April 1970 [16 April 1969 29 May 1969] 17436/70 Heading C2C Ozonides and benzodiazepines are prepared by the following route (R 1 =H, halogen, C 1-4 alkyl, NO 2 CF 3 ; R 2 =H, halogen; R 3 , 4 =H, C 1-4 alkyl; X=halogen), optionally followed by salt formation. The ozonide is obtained by treating (II) with ozone, and affords (I) by reaction with a hydrazine derivative. (II) may alternatively be prepared by acylating a compound of the Formula (VII) with (IV) and heating the product of the Formula (V) (VII) may be prepared by reacting the appropriate phenylhydrazine and aldehyde or ketone, and converted to (III) by Fischer cyclization. Alternatively, (III) may be prepared directly from the phenylhydrazine and aldehyde or ketone.