SE340457
Process, and intermediates useful therein, for obtaining certain 1,2,3,4,5,6-hexahydro-8-(H or OH)-2,6-methano-3-benzazocines valuable as pharmaceutical intermediates by catalytic hydrogenolysis of the corresponding N-benzyl compounds, the latter being produced by Grignard reaction of a benzylmagnes...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Zusammenfassung: | Process, and intermediates useful therein, for obtaining certain 1,2,3,4,5,6-hexahydro-8-(H or OH)-2,6-methano-3-benzazocines valuable as pharmaceutical intermediates by catalytic hydrogenolysis of the corresponding N-benzyl compounds, the latter being produced by Grignard reaction of a benzylmagnesium halide with an N-benzyl-pyridinium halide to yield an N-benzyl-2-benzyl-1,2-dihydropyridine, reducing this to the corresponding tetrahydropyridine, and cyclizing this product by heating with a strong mineral acid to obtain the 1,2,3,4,5,6-hexahydro-3-benzyl-8-(H or OH)-2,6-methano-3-benzazocine. |
|---|