INTERMEDIATE PRODUCT FOR STEROID DERIVATIVES SYNTHESIS, METHOD OF SYNTHESIS

FIELD: organic chemistry, steroids. SUBSTANCE: product: compounds of the formulaused as intermediate reagents for synthesis of compounds of the formulawhere: R- hydrogen, alkyl, aryl-substituted alkyl or alkyl substituted with aromatic heterocycle; R- aryl-substituted alkyl or alkyl substituted with...

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Hauptverfasser:	TAKAKAZU KHAMADA, KOITI KODZIMA, KHIROJOSI KHORIKOSI, KHITOSI KURATA, KOKI ISIBASI
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS STEROIDS
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Beschreibung
Zusammenfassung:	FIELD: organic chemistry, steroids. SUBSTANCE: product: compounds of the formulaused as intermediate reagents for synthesis of compounds of the formulawhere: R- hydrogen, alkyl, aryl-substituted alkyl or alkyl substituted with aromatic heterocycle; R- aryl-substituted alkyl or alkyl substituted with aromatic heterocycle or diarylamino; R- carboxy-group or group of the formula -CONH-SORwhere R- alkyl; and its pharmaceutically acceptable salts and esters exhibiting 5α-reductase activity. The latters can be used for treatment and prophylaxis of prostate hyperthrophy and other disorders caused by the increased level of 5a-dihydrotestosterone level. EFFECT: improved method of synthesis, enhanced effectiveness of treatment and prophylaxis. Предложены соединения формулы IV, используемые в качестве промежуточных при получении соединений формулы I. Формулы I и IV приведены в описании. Предложены также фармацевтически приемлемые соли и сложные эфиры, имеющие ценную 5альфа-редуктазную активность, которые поэтому могут использоваться для лечения и профилактики, кроме прочих заболеваний, и гипертрофию простаты и других расстройств, вызываемых повышенными уровнями 5альфа-дигидротестостерона.