NEW BIOLOGICALLY ACTIVE N-ACYLPROLYLDIPEPTIDES SHOWING ANTIAMNESIC, ANTIHYPOXIC AND ANOREXIC ACTIONS, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND DRUG CONTAINING THEREOF

FIELD: organic chemistry, chemistry of peptides. SUBSTANCE: product: compound of the formula (I). Invention describes new class of N-acylprolyldipeptides that show psychotropic activity and promotes the improved learning and memory. Proposed N-acylprolylpeptides of the formula (I)where R= (C-C)-alky...

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Hauptverfasser: VORONINA T.A, GUDASHEVA T.A, GARIBOKA T.L, KHEHJLIKAS DZHEJMS ANASTASIO, OSTROVSKAJA R.JU, SKOLDINOV A.P, TROFIMOV S.S, SEREDENIN S.B, ROZANTSEV G.G
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creator VORONINA T.A
GUDASHEVA T.A
GARIBOKA T.L
KHEHJLIKAS DZHEJMS ANASTASIO
OSTROVSKAJA R.JU
SKOLDINOV A.P
TROFIMOV S.S
SEREDENIN S.B
ROZANTSEV G.G
description FIELD: organic chemistry, chemistry of peptides. SUBSTANCE: product: compound of the formula (I). Invention describes new class of N-acylprolyldipeptides that show psychotropic activity and promotes the improved learning and memory. Proposed N-acylprolylpeptides of the formula (I)where R= (C-C)-alkyl, cycloalkyl, aralkyl or aryl; R= H, (C-C)-alkyl, carbamidoalkyl or carbalkoxyalkyl; R= NH,, NH (alkyl), N( )OH or alkoxy; and n = 0-3, preferably, 0-2. EFFECT: improved method of synthesis, new biological activities. Биологически активные N-ацетилпролилдидептиды, обладающие антиамнестическим, антигипоксическим и анорексигенным действием, Описан новый класс N-ацилпролилдипептидов, которые обладают психотропной активностью и в частности способствуют улучшению способности к обучению и памяти.
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SUBSTANCE: product: compound of the formula (I). Invention describes new class of N-acylprolyldipeptides that show psychotropic activity and promotes the improved learning and memory. Proposed N-acylprolylpeptides of the formula (I)where R= (C-C)-alkyl, cycloalkyl, aralkyl or aryl; R= H, (C-C)-alkyl, carbamidoalkyl or carbalkoxyalkyl; R= NH,, NH (alkyl), N( )OH or alkoxy; and n = 0-3, preferably, 0-2. EFFECT: improved method of synthesis, new biological activities. 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SUBSTANCE: product: compound of the formula (I). Invention describes new class of N-acylprolyldipeptides that show psychotropic activity and promotes the improved learning and memory. Proposed N-acylprolylpeptides of the formula (I)where R= (C-C)-alkyl, cycloalkyl, aralkyl or aryl; R= H, (C-C)-alkyl, carbamidoalkyl or carbalkoxyalkyl; R= NH,, NH (alkyl), N( )OH or alkoxy; and n = 0-3, preferably, 0-2. EFFECT: improved method of synthesis, new biological activities. 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SUBSTANCE: product: compound of the formula (I). Invention describes new class of N-acylprolyldipeptides that show psychotropic activity and promotes the improved learning and memory. Proposed N-acylprolylpeptides of the formula (I)where R= (C-C)-alkyl, cycloalkyl, aralkyl or aryl; R= H, (C-C)-alkyl, carbamidoalkyl or carbalkoxyalkyl; R= NH,, NH (alkyl), N( )OH or alkoxy; and n = 0-3, preferably, 0-2. EFFECT: improved method of synthesis, new biological activities. Биологически активные N-ацетилпролилдидептиды, обладающие антиамнестическим, антигипоксическим и анорексигенным действием, Описан новый класс N-ацилпролилдипептидов, которые обладают психотропной активностью и в частности способствуют улучшению способности к обучению и памяти.</abstract><oa>free_for_read</oa></addata></record>
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title NEW BIOLOGICALLY ACTIVE N-ACYLPROLYLDIPEPTIDES SHOWING ANTIAMNESIC, ANTIHYPOXIC AND ANOREXIC ACTIONS, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND DRUG CONTAINING THEREOF
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