NEW BIOLOGICALLY ACTIVE N-ACYLPROLYLDIPEPTIDES SHOWING ANTIAMNESIC, ANTIHYPOXIC AND ANOREXIC ACTIONS, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND DRUG CONTAINING THEREOF

FIELD: organic chemistry, chemistry of peptides. SUBSTANCE: product: compound of the formula (I). Invention describes new class of N-acylprolyldipeptides that show psychotropic activity and promotes the improved learning and memory. Proposed N-acylprolylpeptides of the formula (I)where R= (C-C)-alky...

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Hauptverfasser:	VORONINA T.A, GUDASHEVA T.A, GARIBOKA T.L, KHEHJLIKAS DZHEJMS ANASTASIO, OSTROVSKAJA R.JU, SKOLDINOV A.P, TROFIMOV S.S, SEREDENIN S.B, ROZANTSEV G.G
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	FIELD: organic chemistry, chemistry of peptides. SUBSTANCE: product: compound of the formula (I). Invention describes new class of N-acylprolyldipeptides that show psychotropic activity and promotes the improved learning and memory. Proposed N-acylprolylpeptides of the formula (I)where R= (C-C)-alkyl, cycloalkyl, aralkyl or aryl; R= H, (C-C)-alkyl, carbamidoalkyl or carbalkoxyalkyl; R= NH,, NH (alkyl), N( )OH or alkoxy; and n = 0-3, preferably, 0-2. EFFECT: improved method of synthesis, new biological activities. Биологически активные N-ацетилпролилдидептиды, обладающие антиамнестическим, антигипоксическим и анорексигенным действием, Описан новый класс N-ацилпролилдипептидов, которые обладают психотропной активностью и в частности способствуют улучшению способности к обучению и памяти.