DNA, VECTOR, CELL, METHOD OF PREPARING HUMAN BILE ACID SALT-STIMULATED LIPASE/CARBOXYL-ESTER LIPASE, EXPRESSING SYSTEM, HYBRID GENE, MAMMALIAN CELL, METHOD OF CONSTRUCTION OF TRANSGENIC MAMMAL, TRANSGENIC MAMMAL, PROGENY OF TRANSGENIC MAMMAL, MILK, CHILD'S NUTRITION, METHOD OF PREPARING CHILD'S NUTRITION, USE OF DNA

FIELD: molecular biology. SUBSTANCE: invention relates to DNA containing intron sequences and encoding the human enzyme named as bile acid salt-stimulated lipase or carboxyl-ester lipase. DNA molecule is used for producing recombinant human lipases preferably by producing in transgenic mammals but n...

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Hauptverfasser:	KURT SVEN MAGNUS EHNERBEKK, UL'F FREDRIK PONTUS LIDBERG, STIG LENNART KHANSSON, JAN BIRGER FREDRIK TERNELL, KARL GUNNAR B'JURSEL', ZHANETT ANNIKA NIL'SSON, PETER NIL'S IVAR KARLSSON
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DAIRY PRODUCTS, e.g. MILK, BUTTER, CHEESE ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE FISHING FOODS OR FOODSTUFFS FORESTRY HUMAN NECESSITIES HUNTING HYGIENE MAKING THEREOF MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MILK OR CHEESE SUBSTITUTES MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPIRITS THEIR TREATMENT, NOT COVERED BY OTHER CLASSES TRAPPING VINEGAR WINE
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Zusammenfassung:	FIELD: molecular biology. SUBSTANCE: invention relates to DNA containing intron sequences and encoding the human enzyme named as bile acid salt-stimulated lipase or carboxyl-ester lipase. DNA molecule is used for producing recombinant human lipases preferably by producing in transgenic mammals but not in human organisms. Recombinant human lipases can be used for infant feeding as mother milk substituents or for preparing medicinal agents for treatment, for example: malabsorption, mucoviscidosis and chronic pancreatitis. EFFECT: improved method of preparing, enhanced effectiveness of treatment and nutrition. Настоящее изобретение относится к молекуле ДНК, содержащей интронные последовательности и кодирующей человечий белок, который в зависимости от места действия называют стимулируемой солями желчных кислот липазой (ССЖЛ) или карбоксил-сложноэфирной липазой (КСЛ). Молекулу ДНК с успехом применяют в продуцировании рекомбинантных человечьих ССЖЛ/КСЛ, предпочтительно путем продуцирования в трансгенных, отличных от человека млекопитающих. Рекомбинантные человечьи ССЖЛ/КСЛ могут применяться в качестве компонента детского питания, применяемого для кормления младенцев в виде заменителя материнского молока, или для изготовления лекарственных средств для лечения, например: малабсорбции, муковисцидоза и хронического панкреатита.