DOMAIN OF PROTEASE INHIBITOR, DNA, VECTOR, CELL, METHOD OF PREPARING PROTEASE INHIBITOR, PHARMACEUTICAL COMPOSITION, USE OF DOMAIN

FIELD: molecular biology, biochemistry. SUBSTANCE: variant of domain III of Kunits protease inhibitor that is an inhibitor of tissue factor metabolism. Indicated variant shows amino acid sequence where Xis H or 1-5 natural amino acid residues for exception with Cys; each of X-Xmeans independently th...

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Hauptverfasser:	OLE VIL'STED OL'SEN, LARS KRISTIAN PETERSEN, KELL' NORRIS, SEREN EHRIK B'ERN, FANNI NORRIS
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS SUGARS TRAPPING VINEGAR WINE
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Beschreibung
Zusammenfassung:	FIELD: molecular biology, biochemistry. SUBSTANCE: variant of domain III of Kunits protease inhibitor that is an inhibitor of tissue factor metabolism. Indicated variant shows amino acid sequence where Xis H or 1-5 natural amino acid residues for exception with Cys; each of X-Xmeans independently the natural amino acid residue; Xmeans OH or 1-5 natural amino acid residues for exception with Cys; at condition that at least one of amino acid residues X-Xdistincts from the corresponding amino acid of the native sequence. EFFECT: improved method of protease inhibitor preparing. Вариант домена III ингибитора протеазы типа Кунитца, а именно, ингибитора метаболизма тканевого фактора, причем указанный вариант имеет аминокислотную последовательность (I), где Хпредставляет собой Н или 1 - 5 природных аминокислотных остатков за исключением Cys; каждый из Х- Х независимо представляет собой природный аминокислотный остаток; Х представляет собой ОН или 1 - 5 природных аминокислотных остатков за исключением Cys при условии, что по крайней мере один из аминокислотных остатков Х- Х отличается от соответствующего аминокислотного остатка нативной последовательности.