DOMAIN I OF PROTEASE INHIBITOR, DNA, VECTOR, CELL, METHOD OF PROTEASE INHIBITOR PREPARING, PHARMACEUTICAL COMPOSITION, THE USE OF DOMAIN I

FIELD: biochemistry, molecular biology. SUBSTANCE: variant of domain I of human protease inhibitor of Kunitz type has the following amino acid sequence: X-Cys-Ala- -Phe-Lys-Ala-Asp-X-Gly-X-Cys-X, X, X, X, X, X-Phe-Phe-Phe-Asn-Ile-Phe- -Thr-Arg-Glu-Cys-Glu-Glu-Phe-X-Tyr-Gly-Gly-Cys-X, X, X-Gln-Asn- -...

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Hauptverfasser:	OLE VIL'STED OL'SEN, LARS KRISTIAN PETERSEN, KELL' NORRIS, SEREN EHRIK B'ERN, FANNI NORRIS
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TRAPPING VINEGAR WINE
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Beschreibung
Zusammenfassung:	FIELD: biochemistry, molecular biology. SUBSTANCE: variant of domain I of human protease inhibitor of Kunitz type has the following amino acid sequence: X-Cys-Ala- -Phe-Lys-Ala-Asp-X-Gly-X-Cys-X, X, X, X, X, X-Phe-Phe-Phe-Asn-Ile-Phe- -Thr-Arg-Glu-Cys-Glu-Glu-Phe-X-Tyr-Gly-Gly-Cys-X, X, X-Gln-Asn- -Arg-Phe-X-Ser-Leu-Glu-Glu-Cys-X, X-Met-Cys-Thr-Arg-X(sequence D N1) where Xmeans H or 1-7 natural amino acid residues for exception Cys; every of X-Xindependently means natural amino acid residue and Xmeans OH or 1-5 natural amino acid residues for exception Cys; condition: at least one of amino acid residues X-Xdistincts of the corresponding amino acid residue of natural sequence. EFFECT: improved method of inhibitor preparing. Вариант домена 1 ингибитора протеазы человека типа Кунитца, а именно ингибитора метаболизма тканевого фактора (TFP1), где указанный вариант содержит следующую аминокислотную последовательность: Х, Суs, Аlа, Phe, Lуs, Аlа, Аsр, Х, Gly, Х, Суs, Х, Х, Х, Х, Х, Х, Phe, Phe, Phe, Asn, Ile, Phe, Thr, Arg, Gln, Cys, Glu, Glu, Phe, X, Туr, Gly, Gly, Cys, X, X, X, Gln, Asn, Arg, Phe, X, Ser, Leu, Glu, Glu, Cys, X, X, Met, Cys, Thr, Arg, X(SEQ D N 1), где Х- Н или 1 - 7 натуральных аминокислотных остатков, за исключением Суs; каждый из Х- Х- независимо натуральный аминокислотный остаток, а Х- OH или 1 - 5 натуральных аминокислотных остатков, за исключением Суs; при условии, что по крайней мере один из аминокислотных остатков Х- Хотличается от соответствующего аминокислотного остатка нативной последовательности.