BIFUNCTIONAL VARIANTS OF UROKINASE WITH IMPROVED FIBRINOLYTIC PROPERTIES AND ACTION INHIBITING THROMBIN

FIELD: biochemistry, enzymology. SUBSTANCE: invention describes the bifunctional variants of urokinase with the improved fibrinolytic properties and capability to inhibit thrombin activity, plasmids used for these polypeptides preparing and thrombolytics containing bifunctional variant of urokinase...

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Bibliographische Detailangaben
Hauptverfasser:	DEREK DZHON SONDERS, GERD J.SHTEFFENS, STEFAN VNENDT, JOKHANNES SHNAJDER, REGINA KHAJNTSEL'-VILAND
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	FIELD: biochemistry, enzymology. SUBSTANCE: invention describes the bifunctional variants of urokinase with the improved fibrinolytic properties and capability to inhibit thrombin activity, plasmids used for these polypeptides preparing and thrombolytics containing bifunctional variant of urokinase as biologically active substance. EFFECT: improved properties of preparation. Предложены бифункциональные варианты урокиназы с улучшенными фибринолитическими свойствами и ингибирующим тромбин действием, применяемые при получении этих полипептидов плазмиды, а также тромболитические средства, которые в качестве биологически активного вещества содержат бифункциональный варинт урокиназы.