LIPOPEPTIDES FROM ACTINOPLANES SP, METHOD OF THEIR PREPARING AND USE

FIELD: medicine, biochemistry. SUBSTANCE: invention is related with lipopeptides with expressed homological amino acid sequence but with different fatty acid radicals (lipid moiety) which were synthesized from Actinoplanes sp. in the process of fermentation and isolated from the cultural fluid; meth...

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Hauptverfasser: PETER KHAMMANN, JOKHANNES MAJV, GERKHARD ZAJBERT, LASLO VERTESHI, ASTRID MARK, JOAKHIM VINK
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creator PETER KHAMMANN
JOKHANNES MAJV
GERKHARD ZAJBERT
LASLO VERTESHI
ASTRID MARK
JOAKHIM VINK
description FIELD: medicine, biochemistry. SUBSTANCE: invention is related with lipopeptides with expressed homological amino acid sequence but with different fatty acid radicals (lipid moiety) which were synthesized from Actinoplanes sp. in the process of fermentation and isolated from the cultural fluid; methods of isolation and purification of lipopeptides from the cultural medium; the use of lipopeptides as pharmacologically active substances, in part, against gram-positive bacteria, and also the strain Actinoplanes sp. DSM 7358 used for preparing lipopeptides indicated. EFFECT: improved method of preparing and purification of lipopeptides. Изобретение касается липопептидов с ярко выраженной гомологической последовательностью аминокислот, но с различными радикалами жирных кислот (липидной частью), синтезируемых из Actinoplanes sp. в процессе ферментации и выделяемых из культуральной среды, способов выделения липопептидов из культуральной среды и их очистки, применения липопептидов в качестве фармакологически активных веществ, в частности против грам-положительных бактерий, а также штаммов Actinoplanes sp. DSM 7358 для получения указанных липопептидов.
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SUBSTANCE: invention is related with lipopeptides with expressed homological amino acid sequence but with different fatty acid radicals (lipid moiety) which were synthesized from Actinoplanes sp. in the process of fermentation and isolated from the cultural fluid; methods of isolation and purification of lipopeptides from the cultural medium; the use of lipopeptides as pharmacologically active substances, in part, against gram-positive bacteria, and also the strain Actinoplanes sp. DSM 7358 used for preparing lipopeptides indicated. EFFECT: improved method of preparing and purification of lipopeptides. 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SUBSTANCE: invention is related with lipopeptides with expressed homological amino acid sequence but with different fatty acid radicals (lipid moiety) which were synthesized from Actinoplanes sp. in the process of fermentation and isolated from the cultural fluid; methods of isolation and purification of lipopeptides from the cultural medium; the use of lipopeptides as pharmacologically active substances, in part, against gram-positive bacteria, and also the strain Actinoplanes sp. DSM 7358 used for preparing lipopeptides indicated. EFFECT: improved method of preparing and purification of lipopeptides. Изобретение касается липопептидов с ярко выраженной гомологической последовательностью аминокислот, но с различными радикалами жирных кислот (липидной частью), синтезируемых из Actinoplanes sp. в процессе ферментации и выделяемых из культуральной среды, способов выделения липопептидов из культуральной среды и их очистки, применения липопептидов в качестве фармакологически активных веществ, в частности против грам-положительных бактерий, а также штаммов Actinoplanes sp. DSM 7358 для получения указанных липопептидов.</abstract><oa>free_for_read</oa></addata></record>
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subjects BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROCESSES USING MICROORGANISMS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
title LIPOPEPTIDES FROM ACTINOPLANES SP, METHOD OF THEIR PREPARING AND USE
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