LIPOPEPTIDES FROM ACTINOPLANES SP, METHOD OF THEIR PREPARING AND USE

FIELD: medicine, biochemistry. SUBSTANCE: invention is related with lipopeptides with expressed homological amino acid sequence but with different fatty acid radicals (lipid moiety) which were synthesized from Actinoplanes sp. in the process of fermentation and isolated from the cultural fluid; meth...

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Hauptverfasser:	PETER KHAMMANN, JOKHANNES MAJV, GERKHARD ZAJBERT, LASLO VERTESHI, ASTRID MARK, JOAKHIM VINK
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	FIELD: medicine, biochemistry. SUBSTANCE: invention is related with lipopeptides with expressed homological amino acid sequence but with different fatty acid radicals (lipid moiety) which were synthesized from Actinoplanes sp. in the process of fermentation and isolated from the cultural fluid; methods of isolation and purification of lipopeptides from the cultural medium; the use of lipopeptides as pharmacologically active substances, in part, against gram-positive bacteria, and also the strain Actinoplanes sp. DSM 7358 used for preparing lipopeptides indicated. EFFECT: improved method of preparing and purification of lipopeptides. Изобретение касается липопептидов с ярко выраженной гомологической последовательностью аминокислот, но с различными радикалами жирных кислот (липидной частью), синтезируемых из Actinoplanes sp. в процессе ферментации и выделяемых из культуральной среды, способов выделения липопептидов из культуральной среды и их очистки, применения липопептидов в качестве фармакологически активных веществ, в частности против грам-положительных бактерий, а также штаммов Actinoplanes sp. DSM 7358 для получения указанных липопептидов.