NEW N4-MODIFIED 5-METHYL-2'-DEOXYCYTIDINES EXHIBITING ANTIMICOTIC ACTIVITY

FIELD: organic chemistry.SUBSTANCE: invention relates to the field of organic chemistry and microbiology and is intended to suppress the growth of fungi that are biodestructors of cultural heritage objects. New N4-derivatives of 5-methyl-2'-deoxycytidine are proposed, represented by the general...

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Hauptverfasser:	Solev Pavel Nikolaevich, Potapov Mark Pavlovich, Negrya Sergej Dmitrievich, Avdanina Darya Aleksandrovna, Nuraeva Gulgina Kamilovna, Zhgun Aleksandr Aleksandrovich, Shevchenko Oleg Viktorovich, Kochetkov Sergej Nikolaevich, Shitov Mikhail Valerievich, Yasko Maksim Vladimirovich, Aleksandrova Lyudmila Aleksandrovna, Karpenko Inna Leonidovna, Troyan Egor Vladimirovich
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY DECORATIVE ARTS DERIVATIVES THEREOF METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PAINTING OR ARTISTIC DRAWING, NOT OTHERWISE PROVIDEDFOR PERFORMING OPERATIONS PRESERVING PAINTINGS SUGARS SURFACE TREATMENT TO OBTAIN SPECIAL ARTISTIC SURFACE EFFECTSOR FINISHES TRANSPORTING
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Zusammenfassung:	FIELD: organic chemistry.SUBSTANCE: invention relates to the field of organic chemistry and microbiology and is intended to suppress the growth of fungi that are biodestructors of cultural heritage objects. New N4-derivatives of 5-methyl-2'-deoxycytidine are proposed, represented by the general formula where: R1and R2independently mean: R1= -CnH2n+1, -OCnH2n+1(n=8-12); R2= -OH, -N3, -NH2, -NHC(O)CH3, -N(CH3)2, -NHC2H5, -N(C2H5)2, -O(CH2CH2O)3H, which are capable of suppressing the growth of mycelial fungi.EFFECT: effective inhibition of the growth of fungi biodestructing cultural heritage objects.2 cl, 6 dwg, 1 tbl, 23 ex Изобретение относится к области органической химии и микробиологии и предназначено для подавления роста грибов-биодеструкторов объектов культурного наследия. Предложены новые N4-производные 5-метил-2'-дезоксицитидина представленные общей формулой где: R1и R2независимо друг от друга означают: R1=-CnH2n+1, -OCnH2n+1(n=8-12); R2=-OH, -N3, -NH2, -NHC(O)CH3, -N(CH3)2, -NHC2H5, -N(C2H5)2, -O(CH2CH2O)3H, которые способны подавлять рост мицелиальных грибов. Технический результат: эффективное ингибиторование роста грибов-биодеструкторов объектов культурного наследия. 1 з.п. ф-лы, 1 табл., 23 пр., 6 ил.