ARTIFICIAL ANTIGEN-PRESENTING CELLS AND METHODS FOR THEIR APPLICATION

FIELD: biotechnology.SUBSTANCE: invention relates to the field of biotechnology, in particular to an artificial antigen-presenting cell (aAPC), as well as to the method for its preparation. Also disclosed is the use of the above cell in a method for activating an antigen-specific T-cell, a method fo...

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Bibliographische Detailangaben
Hauptverfasser:	CHEN, Tiffany, Fen-Yi, DOWDEN, Nathan, J, SALVAT, Regina, Sophia, ELLOUL, Sivan, WICKHAM, Thomas, Joseph
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	FIELD: biotechnology.SUBSTANCE: invention relates to the field of biotechnology, in particular to an artificial antigen-presenting cell (aAPC), as well as to the method for its preparation. Also disclosed is the use of the above cell in a method for activating an antigen-specific T-cell, a method for inducing T-cell proliferation, a method for expanding a subpopulation from a T-cell population, as well as in a method for inducing a T-cell response to the HPV-E7 antigen.EFFECT: invention is effective for the treatment of an individual with HPV-positive malignant neoplasm.34 cl, 17 dwg, 29 tbl, 27 ex Изобретение относится к области биотехнологии, в частности к искусственной антигенпрезентирующей клетке (aAPC), а также к способу ее получения. Также раскрыто применение вышеуказанной клетки в способе активации антигенспецифической T-клетки, способе индуцирования пролиферации T-клетки, способе экспансии субпопуляции из популяции T-клеток, а также в способе индуцирования T-клеточного ответа на антиген HPV-E7. Изобретение эффективно для лечения индивидуума, имеющего HPV-положительное злокачественное новообразование. 7 н. и 27 з.п. ф-лы, 17 ил., 29 табл., 27 пр.