ADAMANTYL-CONTAINING DERIVATIVES OF 1,2,4-TRIAZOLE AND 1,3,4-THIADIAZOLE HAVING MONOTERPENOID FRAGMENTS USED AS INHIBITORS OF THE ENZYME TYROSYL-DNA PHOSPHODIESTERASE 1

FIELD: molecular biology; biochemistry.SUBSTANCE: invention relates to molecular biology, biochemistry and biotechnology, specifically to adamantyl-monoterpene hybrids articulated through 1,3,4-thiadiazole-2-amine and 1H-1,2,4-triazole-3-thiol fragments. The use of adamantyl-containing derivatives o...

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Hauptverfasser:	Zakharenko Aleksandra Leonidovna, Suslov Evgenij Vladimirovich, Volcho Konstantin Petrovich, Chepanova Arina Aleksandrovna, Salakhutdinov Nariman Faridovich, Munkuev Aldar Ayurovich, Lavrik Olga Ivanovna
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Zusammenfassung:	FIELD: molecular biology; biochemistry.SUBSTANCE: invention relates to molecular biology, biochemistry and biotechnology, specifically to adamantyl-monoterpene hybrids articulated through 1,3,4-thiadiazole-2-amine and 1H-1,2,4-triazole-3-thiol fragments. The use of adamantyl-containing derivatives of 1,2,4-triazole and 1,3,4-thiadiazole with monoterpenoid fragments as inhibitors of the human tyrosyl-DNA phosphodiesterase 1 enzyme is proposed.EFFECT: invention expands the arsenal of inhibitors of this enzyme and can be used to develop drugs applicable in antitumor therapy.1 cl, 1 tbl, 8 ex, 6 dwg Изобретение относится к молекулярной биологии, биохимии и биотехнологии, конкретно к адамантил-монотерпеновым гибридам, сочлененным через 1,3,4-тиадиазол-2-аминовый и 1H-1,2,4-триазол-3-тиольный фрагменты. Предложено применение адамантилсодержащих производных 1,2,4-триазола и 1,3,4-тиадиазола, имеющих монотерпеноидные фрагменты, в качестве ингибиторов фермента тирозил-ДНК-фосфодиэстеразы 1 человека. Изобретение расширяет арсенал ингибиторов данного фермента и может быть использовано для разработки лекарственных препаратов, применимых в противоопухолевой терапии. 1 табл., 8 пр., 6 схем.