PHENYL [A]INDOLE [2,3-G] QUINOLYSINS, THEIR PREPARATION METHOD, COMPOSITIONS CONTAINING THEM AND APPLICATION OPTIONS

FIELD: pharmaceutics.SUBSTANCE: invention relates to a condensed heterocyclic compound of the general formula (I) or its enantiomer, diastereomer, racemate and mixture thereof, where R1and R2are each independently selected from a group consisting of hydrogen, substituted or unsubstituted C1-C4 alkyl, substituted or unsubstituted C6-C10 aryl; and R1and R2are not both hydrogen or R1and R2and neighboring -(CH2)n-O and bound carbon atoms together form unsubstituted 5-element heterocyclic ring, wherein the specified heterocyclic ring is thiophene; each R3, R4is independently selected from a group consisting of hydrogen, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C6-C10 aryl, substituted or unsubstituted 5-element heterocyclic ring, which is selected from thiophene, furan and pyrrole, unsubstituted benzyl, -SO2R9; R5is selected from a group consisting of hydrogen or halogen; R6and R7are each independently selected from a group consisting of hydrogen, unsubstituted C1-C2 alkyl, unsubstituted C1-C2 alkoxy, -OSO2R9; R8is hydrogen; R9and R10are independently hydrogen, unsubstituted C1-C6 alkyl or unsubstituted C6 cycloalkyl, C6-C10 aryl unsubstituted or substituted with 1 halogen, benzyl; wherein, if both of R3and R4are hydrogen, then at least one of R1, R2, R6, R7is a group selected from a group consisting of substituted C6-C10 aryl; where "substituted" means that one, two or three hydrogen atoms in the group are substituted by a substituent selected from a group consisting of halogen, C1-C2 alkyl unsubstituted or substituted with three halogens, C1 alkoxy, hydroxy, cyano, unsubstituted 5-element heterocyclic ring selected from pyrazole, -NR9R10, -SO2R9, -OSO2R9, -COOR9and -OCOR9; n is 1. The invention also relates to specific condensed heterocyclic compounds, a method for obtaining a compound of the formula (I) and a pharmaceutical composition based on a compound of the formula (I).EFFECT: obtaining of a new condensed heterocyclic compounds useful for the treatment of metabolic diseases.13 cl, 6 tbl, 414 ex Изобретение относится к конденсированному гетероциклическому соединению общей формулы (I) или его энантиомеру, диастереомеру, рацемату и их смеси, где R1и R2каждый независимо выбран из группы, состоящей из водорода, замещенного или незамещенного C1-C4 алкила, замещенного или незамещенного C6-C10 арила; и при этом R1и R2не являются одновременно водородом или R1и R2и соседний -(CH2)n-O и связанные атомы углерода вместе образуют незамещ