CRYSTALLINE AND SALT FORMS OF THE TGF-βR1 INHIBITOR AND THE METHOD OF OBTAINING THEM
FIELD: pharmaceutical industry.SUBSTANCE: invention relates to new crystalline forms and salt forms of the TGF-βR1 inhibitor, as well as their use in the preparation of drugs for the treatment of cancer.EFFECT: new crystalline forms of the compounds of formula (I), as well as compounds of formulas (...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; rus |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | DIN, Charlz Z SHI, Sheni KHE, Khuejtszyun KHU, Likhun CHEN, Shukhuej U, Lifan LU, Tszyanyu LI, Tszyan LI, Vejdun |
| description | FIELD: pharmaceutical industry.SUBSTANCE: invention relates to new crystalline forms and salt forms of the TGF-βR1 inhibitor, as well as their use in the preparation of drugs for the treatment of cancer.EFFECT: new crystalline forms of the compounds of formula (I), as well as compounds of formulas (II), (IV), (V), (VI), which have the properties of the TGF-βR1 inhibitor and can be used for the treatment of cancer mediated by inhibition of the TGF- βR1.19 cl, 7 dwg, 5 tbl, 13 ex
Изобретение относится к новым кристаллическим формам и солевым формам ингибитора TGF-βR1, а также их применению при получении лекарственных средств для лечения рака. Технический результат: получены новые кристаллические формы соединения формулы (I), а также соединения формул (II), (IV), (V), (VI), которые обладают свойствами ингибитора TGF-βR1 и могут быть применимы для лечения рака, опосредованного ингибированием TGF-βR1. 7 н. и 12 з.п. ф-лы, 7 ил., 5 табл., 13 пр. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_RU2750702C1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>RU2750702C1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_RU2750702C13</originalsourceid><addsrcrecordid>eNrjZAh1DooMDnH08fH0c1Vw9HNRCHb0CVFw8w_yDVbwd1MI8XBVCHF30z23KchQwdPPw9PJM8Q_CKwQJOXrGuLh7wJS6O8U4ujp5-nnDhL35WFgTUvMKU7lhdLcDApuriHOHrqpBfnxqcUFicmpeakl8UGhRuamBuYGRs6GxkQoAQA36zB0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>CRYSTALLINE AND SALT FORMS OF THE TGF-βR1 INHIBITOR AND THE METHOD OF OBTAINING THEM</title><source>esp@cenet</source><creator>DIN, Charlz Z ; SHI, Sheni ; KHE, Khuejtszyun ; KHU, Likhun ; CHEN, Shukhuej ; U, Lifan ; LU, Tszyanyu ; LI, Tszyan ; LI, Vejdun</creator><creatorcontrib>DIN, Charlz Z ; SHI, Sheni ; KHE, Khuejtszyun ; KHU, Likhun ; CHEN, Shukhuej ; U, Lifan ; LU, Tszyanyu ; LI, Tszyan ; LI, Vejdun</creatorcontrib><description>FIELD: pharmaceutical industry.SUBSTANCE: invention relates to new crystalline forms and salt forms of the TGF-βR1 inhibitor, as well as their use in the preparation of drugs for the treatment of cancer.EFFECT: new crystalline forms of the compounds of formula (I), as well as compounds of formulas (II), (IV), (V), (VI), which have the properties of the TGF-βR1 inhibitor and can be used for the treatment of cancer mediated by inhibition of the TGF- βR1.19 cl, 7 dwg, 5 tbl, 13 ex
Изобретение относится к новым кристаллическим формам и солевым формам ингибитора TGF-βR1, а также их применению при получении лекарственных средств для лечения рака. Технический результат: получены новые кристаллические формы соединения формулы (I), а также соединения формул (II), (IV), (V), (VI), которые обладают свойствами ингибитора TGF-βR1 и могут быть применимы для лечения рака, опосредованного ингибированием TGF-βR1. 7 н. и 12 з.п. ф-лы, 7 ил., 5 табл., 13 пр.</description><language>eng ; rus</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210701&DB=EPODOC&CC=RU&NR=2750702C1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210701&DB=EPODOC&CC=RU&NR=2750702C1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DIN, Charlz Z</creatorcontrib><creatorcontrib>SHI, Sheni</creatorcontrib><creatorcontrib>KHE, Khuejtszyun</creatorcontrib><creatorcontrib>KHU, Likhun</creatorcontrib><creatorcontrib>CHEN, Shukhuej</creatorcontrib><creatorcontrib>U, Lifan</creatorcontrib><creatorcontrib>LU, Tszyanyu</creatorcontrib><creatorcontrib>LI, Tszyan</creatorcontrib><creatorcontrib>LI, Vejdun</creatorcontrib><title>CRYSTALLINE AND SALT FORMS OF THE TGF-βR1 INHIBITOR AND THE METHOD OF OBTAINING THEM</title><description>FIELD: pharmaceutical industry.SUBSTANCE: invention relates to new crystalline forms and salt forms of the TGF-βR1 inhibitor, as well as their use in the preparation of drugs for the treatment of cancer.EFFECT: new crystalline forms of the compounds of formula (I), as well as compounds of formulas (II), (IV), (V), (VI), which have the properties of the TGF-βR1 inhibitor and can be used for the treatment of cancer mediated by inhibition of the TGF- βR1.19 cl, 7 dwg, 5 tbl, 13 ex
Изобретение относится к новым кристаллическим формам и солевым формам ингибитора TGF-βR1, а также их применению при получении лекарственных средств для лечения рака. Технический результат: получены новые кристаллические формы соединения формулы (I), а также соединения формул (II), (IV), (V), (VI), которые обладают свойствами ингибитора TGF-βR1 и могут быть применимы для лечения рака, опосредованного ингибированием TGF-βR1. 7 н. и 12 з.п. ф-лы, 7 ил., 5 табл., 13 пр.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZAh1DooMDnH08fH0c1Vw9HNRCHb0CVFw8w_yDVbwd1MI8XBVCHF30z23KchQwdPPw9PJM8Q_CKwQJOXrGuLh7wJS6O8U4ujp5-nnDhL35WFgTUvMKU7lhdLcDApuriHOHrqpBfnxqcUFicmpeakl8UGhRuamBuYGRs6GxkQoAQA36zB0</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>DIN, Charlz Z</creator><creator>SHI, Sheni</creator><creator>KHE, Khuejtszyun</creator><creator>KHU, Likhun</creator><creator>CHEN, Shukhuej</creator><creator>U, Lifan</creator><creator>LU, Tszyanyu</creator><creator>LI, Tszyan</creator><creator>LI, Vejdun</creator><scope>EVB</scope></search><sort><creationdate>20210701</creationdate><title>CRYSTALLINE AND SALT FORMS OF THE TGF-βR1 INHIBITOR AND THE METHOD OF OBTAINING THEM</title><author>DIN, Charlz Z ; SHI, Sheni ; KHE, Khuejtszyun ; KHU, Likhun ; CHEN, Shukhuej ; U, Lifan ; LU, Tszyanyu ; LI, Tszyan ; LI, Vejdun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_RU2750702C13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; rus</language><creationdate>2021</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>DIN, Charlz Z</creatorcontrib><creatorcontrib>SHI, Sheni</creatorcontrib><creatorcontrib>KHE, Khuejtszyun</creatorcontrib><creatorcontrib>KHU, Likhun</creatorcontrib><creatorcontrib>CHEN, Shukhuej</creatorcontrib><creatorcontrib>U, Lifan</creatorcontrib><creatorcontrib>LU, Tszyanyu</creatorcontrib><creatorcontrib>LI, Tszyan</creatorcontrib><creatorcontrib>LI, Vejdun</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DIN, Charlz Z</au><au>SHI, Sheni</au><au>KHE, Khuejtszyun</au><au>KHU, Likhun</au><au>CHEN, Shukhuej</au><au>U, Lifan</au><au>LU, Tszyanyu</au><au>LI, Tszyan</au><au>LI, Vejdun</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CRYSTALLINE AND SALT FORMS OF THE TGF-βR1 INHIBITOR AND THE METHOD OF OBTAINING THEM</title><date>2021-07-01</date><risdate>2021</risdate><abstract>FIELD: pharmaceutical industry.SUBSTANCE: invention relates to new crystalline forms and salt forms of the TGF-βR1 inhibitor, as well as their use in the preparation of drugs for the treatment of cancer.EFFECT: new crystalline forms of the compounds of formula (I), as well as compounds of formulas (II), (IV), (V), (VI), which have the properties of the TGF-βR1 inhibitor and can be used for the treatment of cancer mediated by inhibition of the TGF- βR1.19 cl, 7 dwg, 5 tbl, 13 ex
Изобретение относится к новым кристаллическим формам и солевым формам ингибитора TGF-βR1, а также их применению при получении лекарственных средств для лечения рака. Технический результат: получены новые кристаллические формы соединения формулы (I), а также соединения формул (II), (IV), (V), (VI), которые обладают свойствами ингибитора TGF-βR1 и могут быть применимы для лечения рака, опосредованного ингибированием TGF-βR1. 7 н. и 12 з.п. ф-лы, 7 ил., 5 табл., 13 пр.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; rus |
| recordid | cdi_epo_espacenet_RU2750702C1 |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | CRYSTALLINE AND SALT FORMS OF THE TGF-βR1 INHIBITOR AND THE METHOD OF OBTAINING THEM |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-30T17%3A33%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=DIN,%20Charlz%20Z&rft.date=2021-07-01&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ERU2750702C1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |