CRYSTALLINE AND SALT FORMS OF THE TGF-βR1 INHIBITOR AND THE METHOD OF OBTAINING THEM

FIELD: pharmaceutical industry.SUBSTANCE: invention relates to new crystalline forms and salt forms of the TGF-βR1 inhibitor, as well as their use in the preparation of drugs for the treatment of cancer.EFFECT: new crystalline forms of the compounds of formula (I), as well as compounds of formulas (...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	DIN, Charlz Z, SHI, Sheni, KHE, Khuejtszyun, KHU, Likhun, CHEN, Shukhuej, U, Lifan, LU, Tszyanyu, LI, Tszyan, LI, Vejdun
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	FIELD: pharmaceutical industry.SUBSTANCE: invention relates to new crystalline forms and salt forms of the TGF-βR1 inhibitor, as well as their use in the preparation of drugs for the treatment of cancer.EFFECT: new crystalline forms of the compounds of formula (I), as well as compounds of formulas (II), (IV), (V), (VI), which have the properties of the TGF-βR1 inhibitor and can be used for the treatment of cancer mediated by inhibition of the TGF- βR1.19 cl, 7 dwg, 5 tbl, 13 ex Изобретение относится к новым кристаллическим формам и солевым формам ингибитора TGF-βR1, а также их применению при получении лекарственных средств для лечения рака. Технический результат: получены новые кристаллические формы соединения формулы (I), а также соединения формул (II), (IV), (V), (VI), которые обладают свойствами ингибитора TGF-βR1 и могут быть применимы для лечения рака, опосредованного ингибированием TGF-βR1. 7 н. и 12 з.п. ф-лы, 7 ил., 5 табл., 13 пр.