UREA COMPOUND, A METHOD FOR PRODUCTION THEREOF AND MEDICAL USE THEREOF

FIELD: pharmaceuticals.SUBSTANCE: invention relates to a compound of general formula (I) or pharmaceutically acceptable salts thereof, where groupis selected from the following structure:, each of R51and R52is independently selected from a group consisting of hydrogen; W and Z are each independently selected from N and C-BR1; in the absence of R1, B are identical or different and each is independently selected from a group consisting of hydrogen, halogen, C1-C6alkyl, wherein said C1-C6alkyl optionally further substituted with one or more groups Q; in the presence of R1, B are identical or different and each is independently selected from a group consisting of -O- and -NR4-; and R1are identical or different and are each independently selected from the group consisting of hydrogen, C1-C6alkyl, heteroaryl, which is a heteroaromatic system containing 1 to 2 heteroatoms, 5 to 6 ring atoms, where the heteroatom is selected from sulfur and nitrogen, -RuORx, -RuC(O)ORx, -RuN(Ry)(Rz), -C(O)N(Ry)(Rz); said alkyl and said heteroaryl is optionally further substituted with one, two or three groups selected from the group consisting of halogen, cyano, hydroxy, C1-C6alkyl, C1-C6alkoxy, C1-C6hydroxyalkoxy, -C(O)NHCH3, heterocyclyl, which is a saturated monocyclic hydrocarbon group containing from 4 to 6 ring atoms, 1 or 2 of which can be replaced with oxygen and/or nitrogen, halophenyl, C3-C6cycloalkyl-tetrazolyl; R4is selected from a group consisting of C1-C6alkyl, or R4and R1together with the nitrogen atom to which they are attached, form piperazinyl, which is further substituted with one group selected from a group consisting of C1-C6alkyl; R2is hydrogen, G is selected from the group:, which is optionally further substituted with one or two groups selected from a group, consisting of C1-C6alkyl, amino, -C(O)-CH=CH2, C3-C6cycloalkyl, phenyl and pyridinyl; wherein said C1-C6alkyl or phenyl can be further substituted with one or three groups selected from a group consisting of halogen, hydroxy, C1-C6alkyl, C1-C6alkoxy, C1-C6haloalkyl, -C(O)OC2H5; R3is selected from Q group; Ruis selected from a bond or C1-C6alkylene; Rxis selected from C1-C6alkyl; Ryand Rzare each independently selected from a group consisting of C1-C6alkyl; or Ryand Rztogether with the nitrogen atom to which they are attached form a heterocyclyl group containing from 6 to 7 ring atoms, which additionally contains 1 heteroatom selected from nitrogen or oxygen, and heterocyclyl group optionally further sub