BICYCLIC TETRAHYDROTHIAZEPINE DERIVATIVES USEFUL FOR TREATING NEOPLASTIC AND/OR INFECTIOUS DISEASES

FIELD: organic chemistry.SUBSTANCE: invention relates to an immunomodulator which is a compound of formula (I) or a pharmaceutically acceptable salt thereof, where Xis S; S(O) or S(O); Xis N or C(R); Rdenotes H or methyl; Rdenotes phenyl; pyridinyl; quinolinyl or thiadiazolyl, where Ris optionally substituted with one or more R, which are identical or different; Ris halogen; CN; OR; C(O)N(RR); Tor Calkyl, wherein Calkyl is optionally substituted with one or more halogens which are the same or different; R, Rare independently selected from a group consisting of H and Calkyl, where Calkyl is optionally substituted with one or more halogens, which are identical; Tis Ccycloalkyl; oxadiazolyl; thiadiazolyl; triazolyl or morpholinyl, where Tis optionally substituted with one R; Rrepresents Calkyl; Ris R; OR; NHRor NHC(O)R; Ris T; Calkyl; Calkenyl or Calkynyl, where Calkyl; Calkenyl and Calkynyl are optionally substituted with one or three R, which are identical or different; Ris halogen; OR; C(O)N(RR); N(R)C(O)R; Tor Calkyl; R, Rare independently selected from a group consisting of H or Calkyl, where Calkyl is optionally substituted with one R; Tis phenyl; Ccycloalkyl; oxanyl; morpholinyl; oxazolyl; pyridinyl; oxolanyl or oxaspiroheptanyl, where Tis optionally substituted with one or two R, which are identical or different; Ris halogen; OR; OC(O)N(RR); Tor Calkyl, where Calkyl is optionally substituted with one to three R, which are identical or different; R, Rare independently selected from a group consisting of H; Calkyl; Calkenyl and Calkynyl, where Calkyl is optionally substituted with one or more R, which are identical; R, Rare independently selected from a group consisting of halogen; OR; C(O)N(RR); or N(R)C(O)R; R, Rare independently selected from a group, consisting of H and Calkyl ; Tis phenyl or morpholinyl; Ris H; F; Cl or N (CH); Ris H or Calkyl, where Calkyl is optionally substituted with one R; Ris N (R)C(O)OR; R, Rare independently selected from a group consisting of H and Calkyl. Invention also relates to a pharmaceutical composition based on the compound of formula (I).EFFECT: technical result is obtaining novel compounds and a pharmaceutical composition based thereon, which can be used in medicine for treating cancer.23 cl, 47 tbl Изобретение относится к органической химии, а именно к иммуномодулятору, представляющему собой соединение формулы (I) или его фармацевтически приемлемую соль, где Xпредставляет собой S; S(O) или S(O); Xпредставляет со