METHOD OF CORRECTION OF MICROCIRCULATION DISORDERS IN PLACENTA WITH CARBAMYLATED DARBEPOETIN IN ADMA-LIKE MODEL OF PREECLAMPSIA

FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to experimental pharmacology, and can be used for correction of microcirculation disorders in placenta with carbamylated darbepoetin in ADMA-like model of preeclampsia. That is ensured by reproducing a model of preeclampsia in Wistar ra...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	Lazareva Galina Anatolevna, Gureeva Elena Gennadievna, Kolesnichenko Pavel Dmitrievich, Pokrovskij Mikhail Vladimirovich, Zhuchenko Maksim Andreevich, Gureeva Anastasiya Vladimirovna, Antsiferova Oksana Evgenevna, Pobeda Anna Sergeevna, Severinova Olga Vladimirovna, Korokina Liliya Viktorovna, Korokin Mikhail Viktorovich, Zhilinkova Lyudmila Anatolevna, Gureev Vladimir Vladimirovich, Peresypkina Anna Aleksandrovna, Gudyrev Oleg Sergeevich, Vajn Darya Sergeevna, Lokteva Tatyana Ivanovna, Pokrovskaya Tatyana Grigorevna, Yakushev Vladimir Ivanovich, Ivakhno Elena Nikolaevna, Yurakova Alesya Viktorovna, Zatolokina Mariya Alekseevna, Pakhomov Sergej Petrovich, Golubev Ivan Vladimirovich, Povetka Elena Evgenevna, Shchurovskaya Kristina Vladimirovna
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	ADVERTISING APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND,DEAF OR MUTE CRYPTOGRAPHY DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY DIAGRAMS DISPLAY EDUCATION EDUCATIONAL OR DEMONSTRATION APPLIANCES GLOBES HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PHYSICS PLANETARIA PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SEALS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to experimental pharmacology, and can be used for correction of microcirculation disorders in placenta with carbamylated darbepoetin in ADMA-like model of preeclampsia. That is ensured by reproducing a model of preeclampsia in Wistar rats by daily intraperitoneal introduction of L-nitro-arginine-methyl ester 25 mg/kg from 14th to 20th day of pregnancy. To correct the simulated pathology, carbamylated darbepoetin is administered subcutaneously in dose of 300 mcg/kg once day on 7th, 10th, 13th, 16th and 19th day of pregnancy.EFFECT: method provides pronounced correction of microcirculation in placenta due to reduction of oxidative stress, stabilization of hemodynamics caused by antioxidant and antiischemic effects of administered preparation.1 cl, 1 tbl, 1 ex Изобретение относится к медицине, а именно к экспериментальной фармакологии, и может быть использовано для коррекции нарушений микроциркуляции в плаценте карбамилированным дарбэпоэтином при ADMA-подобной модели преэклампсии. Для этого воспроизводят модель преэклампсии у крыс линии Wistar путём ежедневного с 14 по 20 сутки беременности внутрибрюшинного введения L-нитро-аргинин-метилового эфира в дозе 25 мг/кг. Для коррекции моделируемой патологии вводят подкожно карбамилированный дарбэпоэтин в дозировке 300 мкг/кг 1 раз в день на 7, 10, 13, 16, 19 сутки беременности. Способ обеспечивает выраженную коррекцию микроциркуляции в плаценте за счёт снижения оксидативного стресса, стабилизации гемодинамики, обусловленных антиоксидантным и противоишемическим эффектами вводимого препарата. 1 табл., 1 пр.