SUBSTITUTED CHROMANS

FIELD: medicine; pharmaceuticals.SUBSTANCE: invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, where X is CRand Y is CR; or X is N and Y is CR; or X is CRand Y is N; m is equal to 0; Rand Reach independently represent hydrogen, halogen, C-Chaloalkyl, C-Calk...

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Bibliographische Detailangaben
Hauptverfasser: KENIG Dzhon R, KIM Filip R, VOJT Erik, GRESZLER Stiven N, Sirl Kseniya B, LYU Bo, EUNG Min S, VAN Syutsin, ALTENBECH Robert Dzh, BOGDAN Endryu
Format: Patent
Sprache:eng ; rus
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Beschreibung
Zusammenfassung:FIELD: medicine; pharmaceuticals.SUBSTANCE: invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, where X is CRand Y is CR; or X is N and Y is CR; or X is CRand Y is N; m is equal to 0; Rand Reach independently represent hydrogen, halogen, C-Chaloalkyl, C-Calkyl, -ORor -C(O)OR; each Rin each case independently represents hydrogen, C-Chaloalkyl or C-Calkyl; where C-Calkyl is substituted with one or two substitutes independently selected from a group consisting of -OR, -C(O)ORand G; Rin each case independently represents hydrogen or C-Calkyl; and Ris hydrogen or C-Calkyl; Rand Reach independently represent hydrogen, halogen, C-Calkyl or -O-(C-Calkyl); Rrepresents hydrogen, C-Chaloalkyl or C-Calkyl; Ris hydrogen, -C(O)R, -C(O)OH, -C(O)O(C-Calkyl), -C(O)N(R), C-Chaloalkyl, C-Calkyl or G; or Rand Rtogether with the carbon atom to which they are attached form C-Ccycloalkyl or 4-6 membered heterocycle, in which one heteroatom is selected from N; wherein each 4-6 membered heterocycle is optionally substituted with 1 group R; G, in each case, independently represents cycloalkyl, 4-6 membered heterocycle, in which one or two heteroatoms are selected from N, O or S, phenyl or 5-6 membered heteroaryl containing 1, 2, 3 or 4 heteroatoms selected from N, O or S, each of which is independently unsubstituted or substituted with 1 or 2 independently selected groups R; Rand R, in each case, each independently represent C-Calkyl, halogen, C-Chaloalkyl, oxo, -OR, -S(O)R, -C(O)R, -C(O)OR, -C(O)N(R)or -C(O)N(R)S(O)R, where each C-Chaloalkyl and C-Calkyl are optionally substituted with one or two substitutes independently selected from a group consisting of -OR; Rin each case independently represents hydrogen, C-Chaloalkyl, C-Calkyl or G, where each C-Chaloalkyl and C-Calkyl are optionally substituted with one or two substitutes independently selected from a group consisting of -ORand G; Rin each case independently represents G; Rdenotes hydrogen; Ris hydrogen or -(C-Calkylenyl)-G; Ris hydrogen; each R, Rand Rindependently represent hydrogen or halogen; each Rand Rindependently represent halogen; G, Gand G, in each case, each independently represent cycloalkyl, indenyl, 3-7-member heterocycle, containing one, two, three or four heteroatoms independently selected from a group consisting of O, N and S, or phenyl, each of which is independently unsubstituted or substituted with 1 or 2 independently selected groups R; where Rin each case indep