PYRIDINES, PYRIMIDINES AND PYRAZINES AS BRUTON'S TYROSINE KINASE INHIBITORS AND USE THEREOF
FIELD: medicine; pharmaceuticals.SUBSTANCE: invention refers to compounds of formula I and their pharmaceutically acceptable compositions.EFFECT: technical result is obtaining novel compounds suitable as Bruton tyrosine kinase inhibitors, which can be used to produce medicinal agents for preventive...
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| creator | TSYU Khoj LYU-BUDZHALSKI Lesli NGUJEN Ngan KOLDVELL Richard D DZHOUNS Rejnaldo MOCHALKIN Igor |
| description | FIELD: medicine; pharmaceuticals.SUBSTANCE: invention refers to compounds of formula I and their pharmaceutically acceptable compositions.EFFECT: technical result is obtaining novel compounds suitable as Bruton tyrosine kinase inhibitors, which can be used to produce medicinal agents for preventive or therapeutic treatment of mediated disorder.11 cl, 1 tbl, 81 ex
Изобретение относится к соединениям формулы I и их фармацевтически приемлемым композициям. Технический результат: получены новые соединения, пригодные в качестве ингибиторов тирозинкиназы Брутона, которые могут применяться для получения лекарственных средств для профилактического или терапевтического лечения опосредованного расстройства. 3 н. и 8 з.п. ф-лы, 1 табл., 81 пр. |
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Изобретение относится к соединениям формулы I и их фармацевтически приемлемым композициям. Технический результат: получены новые соединения, пригодные в качестве ингибиторов тирозинкиназы Брутона, которые могут применяться для получения лекарственных средств для профилактического или терапевтического лечения опосредованного расстройства. 3 н. и 8 з.п. ф-лы, 1 табл., 81 пр.</description><language>eng ; rus</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200127&DB=EPODOC&CC=RU&NR=2712220C2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200127&DB=EPODOC&CC=RU&NR=2712220C2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TSYU Khoj</creatorcontrib><creatorcontrib>LYU-BUDZHALSKI Lesli</creatorcontrib><creatorcontrib>NGUJEN Ngan</creatorcontrib><creatorcontrib>KOLDVELL Richard D</creatorcontrib><creatorcontrib>DZHOUNS Rejnaldo</creatorcontrib><creatorcontrib>MOCHALKIN Igor</creatorcontrib><title>PYRIDINES, PYRIMIDINES AND PYRAZINES AS BRUTON'S TYROSINE KINASE INHIBITORS AND USE THEREOF</title><description>FIELD: medicine; pharmaceuticals.SUBSTANCE: invention refers to compounds of formula I and their pharmaceutically acceptable compositions.EFFECT: technical result is obtaining novel compounds suitable as Bruton tyrosine kinase inhibitors, which can be used to produce medicinal agents for preventive or therapeutic treatment of mediated disorder.11 cl, 1 tbl, 81 ex
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PYRIDINES, PYRIMIDINES AND PYRAZINES AS BRUTON'S TYROSINE KINASE INHIBITORS AND USE THEREOF |
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