PYRIDINES, PYRIMIDINES AND PYRAZINES AS BRUTON'S TYROSINE KINASE INHIBITORS AND USE THEREOF

FIELD: medicine; pharmaceuticals.SUBSTANCE: invention refers to compounds of formula I and their pharmaceutically acceptable compositions.EFFECT: technical result is obtaining novel compounds suitable as Bruton tyrosine kinase inhibitors, which can be used to produce medicinal agents for preventive...

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Bibliographische Detailangaben
Hauptverfasser:	TSYU Khoj, LYU-BUDZHALSKI Lesli, NGUJEN Ngan, KOLDVELL Richard D, DZHOUNS Rejnaldo, MOCHALKIN Igor
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	FIELD: medicine; pharmaceuticals.SUBSTANCE: invention refers to compounds of formula I and their pharmaceutically acceptable compositions.EFFECT: technical result is obtaining novel compounds suitable as Bruton tyrosine kinase inhibitors, which can be used to produce medicinal agents for preventive or therapeutic treatment of mediated disorder.11 cl, 1 tbl, 81 ex Изобретение относится к соединениям формулы I и их фармацевтически приемлемым композициям. Технический результат: получены новые соединения, пригодные в качестве ингибиторов тирозинкиназы Брутона, которые могут применяться для получения лекарственных средств для профилактического или терапевтического лечения опосредованного расстройства. 3 н. и 8 з.п. ф-лы, 1 табл., 81 пр.