INTERLEUKIN 15 PROTEIN COMPLEX AND USE THEREOF

FIELD: biotechnology.SUBSTANCE: invention relates to biotechnology, specifically to a protein complex agonist IL-15, consisting of soluble fusion protein (I) and soluble fusion protein (II), where fused protein (I) is IL-15 (L52C) with SEQ ID NO: 2, and fused protein (II) is selected from IL-15Rα-EC...

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Bibliographische Detailangaben
Hauptverfasser:	TSUJ Dunbin, E Sin, CHZHAN Lyanshan, SUN Pyaoyan, TSYUJ Syandun, KHU Tsiyue, TAO Vejkan
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	FIELD: biotechnology.SUBSTANCE: invention relates to biotechnology, specifically to a protein complex agonist IL-15, consisting of soluble fusion protein (I) and soluble fusion protein (II), where fused protein (I) is IL-15 (L52C) with SEQ ID NO: 2, and fused protein (II) is selected from IL-15Rα-ECD (S40C)-Fc with SEQ ID NO: 5, Fc-IL-15Rα-ECD (S40C) with SEQ ID NO: 6, IL-15Rα-Sushi + (S40C) -Fc with SEQ ID NO: 7 or Fc-IL-15Rα-sushi + (S40C) with SEQ ID NO: 8, and can be used in medicine.EFFECT: obtained protein complex is used for effective treatment IL-15-mediated diseases.10 cl, 11 dwg, 7 tbl, 5 ex Изобретение относится к области биотехнологии, конкретно к белковому комплексу агонист ИЛ-15, состоящему из растворимого слитого белка (I) и растворимого слитого белка (II), где слитый белок (I) представляет собой ИЛ-15(L52C) с SEQ ID NO: 2, а слитый белок (II), выбран из ИЛ-15Rα-ECD(S40C)-Fc с SEQ ID NO: 5, Fc-ИЛ-15Rα-ECD(S40C) с SEQ ID NO: 6, ИЛ-15Rα-Sushi+(S40C)-Fc с SEQ ID NO: 7 или Fc-ИЛ-15Rα-sushi+(S40C) с SEQ ID NO: 8, и может быть использовано в медицине. Полученный белковый комплекс используется для эффективного лечения ИЛ-15-опосредованных заболеваний. 9 н. и 1 з.п. ф-лы, 11 ил., 7 табл., 5 пр.