OXAZOLIDINE-BASED COMPOUND AND ANDROGEN RECEPTOR SELECTIVE AGONIST

FIELD: chemistry.SUBSTANCE: invention relates to a compound of the following chemical formula 1, an enantiomer, a diastereomer or a pharmaceutically acceptable salt thereof, where Ris a substitute of the following chemical formula 2 or chemical formula 3; Ris hydrogen, oxo or C-Calkyl; Rand Reach independently represents a substitute selected from a group consisting of hydrogen and C-Calkyl; Rand Reach independently represents a substitute selected from the group consisting of hydrogen, halogen and C-Calkyl; Ris cyano or nitro, and when Ris cyano and Ris H, then Ris X(CH)Rprovided that if n is 0 and X is O, then Rdoes not represent H; C-Calkyl as Rvalue and Rcontains one or more substitutes selected from a group consisting of hydrogen, hydroxy and halogen; chemical formula 2 is -X(CH)R, where X is O, N(H), S or S(O), Ris hydrogen, piperidine, phenyl or pyridine, which can be substituted (substitutes are given in the claim), n is 0 or 1; chemical formula 3 represents structure (a), where Y is CH or N, m is integer 0, 1 or 2, Rrepresents a substitute selected from a group consisting of hydrogen, oxo, C-Calkyl, cyano, C(O)R, C(O)OR, C(O)NRR, S(O)R, NHC(O)R, NRRand NHC(O)OR, Rand Rare given in the claim, and C-Calkyl contains one or more substitutes selected from a group consisting of hydrogen, hydroxy, halogen and cyano. Invention also relates to specific compounds: oxime (E)-4-(((2R,5S)-3-(3-methyl-4-nitrophenyl)-2-(trifluoromethyl)oxazolidin-5-yl)methoxy)benzaldehyde, 2-chloro-4-((2R,5S)-5-((4-((E)-(hydroxyimino)methyl)phenoxy)methyl)-2-(trifluoromethyl)oxazolidin-3-yl)benzonitrile, 2-chloro-4-((2R,5S)-5-((4-((E)-(hydroxyimino)methyl)phenoxy)methyl)-2-(trifluoromethyl)oxazolidin-3-yl)-3-methylbenzonitrile, 4-((2R,5S)-5-((4-((E)-(methoxyimino)methyl)phenoxy)methyl)-2-(trifluoromethyl)oxazolidin-3-yl)-2-(trifluoromethyl)benzonitrile, 4-((2R,5S)-5-((4-((E)-(hydroxyimino)methyl)phenoxy)methyl)-2-(trifluoromethyl)oxazolidin-3-yl)-2-(trifluoromethyl)benzonitrile, oxime(E)-4-(((2R,5S)-3-(4-nitro-3-(trifluoromethyl)phenyl)-2-(trifluoromethyl)oxazolidin-5-yl)methoxy)benzaldehyde, 4-((2R,5S)-5-((4-((E)-(hydroxyimino)methyl)-2-nitrophenoxy)methyl)-2-(trifluoromethyl)oxazolidin-3-yl)-2-(trifluoromethyl)benzonitrile, (2R,5S)-5-(1-acetylpiperidin-4-yl)-3-(4-cyano-3-(trifluoromethyl)phenyl)-2-(trifluoromethyl)oxazolidine-5-carboxamide or 4-((2R,5S)-5-(1-hydroxy-2-phenylethyl)-2-(trifluoromethyl)oxazolidin-3-yl)-2-(trifluoromethyl)benzonitrile. Invention relates to methods